PlainVitamins

SAMe with Vitamins B-6, B-12 and 5-MTHF

by Designs for Health · capsule · 90 vegetarian capsules

  • On the market (NIH)
  • UPC 8 79452 00377 4
  • DSLD label 22788
  • Serving 1 capsule

SAMe with Vitamins B-6, B-12 and 5-MTHF by Designs for Health lists 4 ingredients, 4 with an amount per serving of 1 capsule, such as 5 mg of vitamin B-6, 100 mcg of folate, 50 mcg of vitamin B12 and 200 mg of SAMe. Its current label entered the NIH Dietary Supplement Label Database on June 25, 2013.

What is in SAMe with Vitamins B-6, B-12 and 5-MTHF?

Each row as the label prints it, per serving of 1 capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

SAMe with Vitamins B-6, B-12 and 5-MTHF: Supplement Facts rows against the market (DSLD label 22788, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin B-6as Pyridoxal 5-PhosphateVitamin B-6 (Form: as Pyridoxal-5-Phosphate)5 mg250%Vitamin B6 in SAMe with Vitamins B-6, B-12 and 5-MTHF against 15,277 products5 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg5 mg

51% of 15,277 products listing vitamin B6 give more (median 6 mg).

Folateas [6s]-5-Methyltetrahydrofolate, Glucosamine SaltFolate (Form: as [6s]-5-Methyltetrahydrofolate, Glucosamine Salt) (Alt. Name: Quatrefolic)100 mcg25%Folate in SAMe with Vitamins B-6, B-12 and 5-MTHF against 7,022 products100 mcg per serving; the middle half of products list 200 mcg to 400 mcg, the median 400 mcg.100 mcg

86% of 7,022 products listing folate give more (median 400 mcg).

Vitamin B12as MethylcobalaminVitamin B-12 (Form: as Methylcobalamin)50 mcg830%Vitamin B12 in SAMe with Vitamins B-6, B-12 and 5-MTHF against 14,425 products50 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg50 mcg

Higher than 51% of 14,425 products listing vitamin B12 (median 36 mcg).

SAMeas S-Adenosyl-L-Methionine Disulfate P-ToluensulfateSAMe (Form: as S-Adenosyl-L-Methionine Disulfate P-Toluensulfate)200 mgSAMe in SAMe with Vitamins B-6, B-12 and 5-MTHF against 163 products200 mg per serving; the middle half of products list 200 mg to 400 mg, the median 200 mg.200 mg

48% of 163 products listing SAMe give more (median 200 mg).

Source: NIH ODS Dietary Supplement Label Database, label 22788 (entered June 25, 2013), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • 86% of the 7,022 products that print an amount of folate list more than its 100 mcg of folate (median 400 mcg).

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

1 product lists the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Recommended Use: As a dietary supplement, take one capsule per day, preferably on an empty stomach, or as directed by your health care practitioner.
Allergens and what it does not contain
Does not contain gluten.
Storage
STORE IN A COOL, DRY PLACE.

Source: label statements in DSLD label 22788.

What else is on the label?

Other ingredients: Microcrystalline Cellulose, Vegetable Stearate, Calcium Chloride Anhydrous, Calcium Oxide.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): MADE WITH NON-GMO INGREDIENTS; Guaranteed GMP COMPLIANT Products.

How many labels does SAMe with Vitamins B-6, B-12 and 5-MTHF have?

2 labels are on file under this name since June 25, 2013: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 22788 (current) Entered June 25, 2013 · on the market · 90 vegetarian capsules · UPC 8 79452 00377 4
  2. Label 22786 Entered June 25, 2013 · on the market · 30 vegetarian capsules · UPC 8 79452 00378 1

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Designs for Health, Inc. (manufacturer, distributor), Suffield, CT. All Designs for Health products.

Where next?