PlainVitamins

SAMe 200 mg + Cofactors

by Metabolic Maintenance · capsule · 60 capsules

  • On the market (NIH)
  • UPC 8 38287 00156 0
  • DSLD label 274194
  • Serving 1 to 2 capsules; amounts per 1 capsule
  • 60 servings

SAMe 200 mg + Cofactors by Metabolic Maintenance lists 10 ingredients, 8 with an amount per serving of 1 capsule, such as 2 mg of vitamin B6, 333 mcg DFE of folate, 500 mcg of vitamin B12 and 20 mg of calcium; 2 sit inside a blend without their own amounts. Its current label entered the NIH Dietary Supplement Label Database on September 22, 2022.

What is in SAMe 200 mg + Cofactors?

Each row as the label prints it, per serving of 1 capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

SAMe 200 mg + Cofactors: Supplement Facts rows against the market (DSLD label 274194, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin B6as Pyridoxal 5-Phosphate2 mg118%Vitamin B6 in SAMe 200 mg + Cofactors against 15,277 products2 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg2 mg

69% of 15,277 products listing vitamin B6 give more (median 6 mg).

Folate333 mcg DFE83%
Calcium L-5-Methylfolatecalcium salt200 mcg
Vitamin B12as Methylcobalamin500 mcg20,833%Vitamin B12 in SAMe 200 mg + Cofactors against 14,425 products500 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg500 mcg

Higher than 82% of 14,425 products listing vitamin B12 (median 36 mcg).

Calciumas Calcium Citrate20 mg2%Calcium in SAMe 200 mg + Cofactors against 17,831 products20 mg per serving; the middle half of products list 50 mg to 252 mg, the median 115 mg.DV 1,300 mgUL 2,500 mg20 mg

91% of 17,831 products listing calcium give more (median 115 mg).

Magnesiumas Magnesium Bisglycinate20 mg5%Magnesium in SAMe 200 mg + Cofactors against 14,003 products20 mg per serving; the middle half of products list 30 mg to 200 mg, the median 86 mg.UL 350 mgDV 420 mg20 mg

83% of 14,003 products listing magnesium give more (median 86 mg).

SAMe200 mgSAMe in SAMe 200 mg + Cofactors against 163 products200 mg per serving; the middle half of products list 200 mg to 400 mg, the median 200 mg.200 mg

48% of 163 products listing SAMe give more (median 200 mg).

S-Adenosyl-L-Methionine Disulfate P-Toluenesulfonate444 mg
Calcium Chlorideno amount given
Calcium Oxideno amount given

Source: NIH ODS Dietary Supplement Label Database, label 274194 (entered September 22, 2022), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • 91% of the 17,831 products that print an amount of calcium list more than its 20 mg of calcium (median 115 mg).

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with SAMe 200 mg + Cofactors's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Best consumed within 90 days after opening.
Directions: One to two (1-2) capsules daily, between meals, or as directed by a healthcare professional.
Warnings
Caution: Pregnant or lactating women, consult your healthcare professional before taking this product.
If you suffer from bipolar (manic) depression, do not use this product.
Keep tightly closed in a cool, dry place, out of the reach of children.
Allergens and what it does not contain
Egg free Gluten free Free of nuts Dairy free

Source: label statements in DSLD label 274194.

What else is on the label?

Other ingredients: L-Leucine, Vegetarian Cellulose, Gellan Gum.

How many labels does SAMe 200 mg + Cofactors have?

One label is on file, entered on September 22, 2022.

  1. Label 274194 (current) Entered September 22, 2022 · on the market · 60 capsules · UPC 8 38287 00156 0

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Metabolic Maintenance (manufacturer), Sisters, Oregon. All Metabolic Maintenance products.

Where next?