PlainVitamins

SAM-e Plus

by Karuna · capsule · 60 delayed release capsules

  • On the market (NIH)
  • UPC 0 18647 09125 1
  • DSLD label 327124
  • Serving 2 capsules
  • 30 servings

SAM-e Plus by Karuna lists 7 ingredients, 7 with an amount per serving of 2 capsules, such as 30 mg of niacin, 2 mg of vitamin B6, 669 mcg DFE of folate and 20 mcg of vitamin B12. Its current label entered the NIH Dietary Supplement Label Database on January 23, 2025.

What is in SAM-e Plus?

Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

SAM-e Plus: Supplement Facts rows against the market (DSLD label 327124, January 2026 release)
IngredientAmount% DVAmong products listing it
Niacinas Niacinamide30 mg188%Niacin in SAM-e Plus against 12,413 products30 mg per serving; the middle half of products list 13.2 mg to 48 mg, the median 20 mg.DV 16 mgUL 35 mg30 mg

Higher than 63% of 12,413 products listing niacin (median 20 mg). Per day at the most servings: 60 mg. 1.7 times the adult UL a day.

Vitamin B6as Pyridoxine Hydrochloride2 mg118%Vitamin B6 in SAM-e Plus against 15,277 products2 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg2 mg

69% of 15,277 products listing vitamin B6 give more (median 6 mg). Per day at the most servings: 4 mg.

Folate669 mcg DFE167%
Folic Acid400 mcg
Vitamin B12as Methylcobalamin20 mcg833%Vitamin B12 in SAM-e Plus against 14,425 products20 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg20 mcg

59% of 14,425 products listing vitamin B12 give more (median 36 mcg). Per day at the most servings: 40 mcg.

Choline Bitartrate50 mg9%Choline in SAM-e Plus against 4,738 products50 mg per serving; the middle half of products list 18 mg to 100 mg, the median 40 mg.DV 550 mgUL 3,500 mg50 mg

Higher than 54% of 4,738 products listing choline (median 40 mg). Per day at the most servings: 100 mg.

SAM-e400 mgSAMe in SAM-e Plus against 163 products400 mg per serving; the middle half of products list 200 mg to 400 mg, the median 200 mg.400 mg

Higher than 53% of 163 products listing SAMe (median 200 mg). Per day at the most servings: 800 mg.

Source: NIH ODS Dietary Supplement Label Database, label 327124 (entered January 23, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • At 2 servings a day, the most its directions give, the label lists 60 mg of niacin, 1.7 times the adult Tolerable Upper Intake Level.

The NIH database records 1 to 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with SAM-e Plus's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested use for adults: Two capsules, up to two times a day (preferably morning and evening), or as directed by your health care practitioner.
Warnings
This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.
Allergens and what it does not contain
This product contains no yeast, wheat, soy, corn, milk, salt, sugar, artificial coloring, preservatives or flavoring.
Storage
Keep in a cool, dry place, tightly capped.

Source: label statements in DSLD label 327124.

What else is on the label?

Other ingredients: Hypromellose, Gellan, Silica, Magnesium Stearate.

How many labels does SAM-e Plus have?

3 labels are on file under this name since August 23, 2013: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 327124 (current) Entered January 23, 2025 · on the market · 60 delayed release capsules · UPC 0 18647 09125 1
  2. Label 262728 Entered May 19, 2022 · off the market September 28, 2023 · 60 tablets · UPC 0 18647 09125 1
  3. Label 25117 Entered August 23, 2013 · off the market September 20, 2021 · 60 tablets · UPC 0 18647 09125 1

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Karuna Corporation (manufacturer), Novato, CA. All Karuna products.

Where next?