SAM-e 400 mg
by HBC Protocols · tablet or pill · 60 tablets
- On the market (NIH)
- DSLD label 74981
- Serving 1 to 4 tablets; amounts per 1 tablet
SAM-e 400 mg by HBC Protocols lists 4 ingredients, 4 with an amount per serving of 1 tablet, such as 400 mg of S-adenosyl-methionine disulfate tosylate, 2 mg of vitamin B6, 50 mcg of vitamin B12 and 200 mcg of folic acid. Its current label entered the NIH Dietary Supplement Label Database on June 23, 2017.
What is in SAM-e 400 mg?
Each row as the label prints it, per serving of 1 tablet. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).
| Ingredient | Amount | % DV | Among products listing it |
|---|---|---|---|
| S-Adenosyl-Methionine Disulfate Tosylate | 400 mg | Higher than 53% of 163 products listing SAMe (median 200 mg). | |
| Vitamin B6 | 2 mg | 118%* | 69% of 15,277 products listing vitamin B6 give more (median 6 mg). |
| Vitamin B12 | 50 mcg | 2,083%* | Higher than 51% of 14,425 products listing vitamin B12 (median 36 mcg). |
| Folic Acid | 200 mcg | 71% of 7,022 products listing folate give more (median 400 mcg). |
* % Daily Value computed from the printed amount and the FDA Daily Value (21 CFR 101.9); the label prints none for that row.
Source: NIH ODS Dietary Supplement Label Database, label 74981 (entered June 23, 2017), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.
Is that a lot?
Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.
The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.
The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.
Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.
Which products have the closest formulas?
1 product lists the very same ingredients; the nearest amounts come first.
- SAMe with Vitamins B-6, B-12 and 5-MTHFDesigns for Health same ingredients
- BlisphoraMetagenics 3 shared, 84% alike
- SAMe 200 mg + CofactorsMetabolic Maintenance 4 shared, 77% alike
- SAM-e PlusKaruna 4 shared, 71% alike
- SAMeOrtho Molecular Products 2 shared, 68% alike
- MasterMindZahler 4 shared, 52% alike
Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.
What does the label say about taking it?
Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.
- Directions
- Directions For Use: Adults take 1 - 4 tablets daily or as directed by your physician.
Source: label statements in DSLD label 74981.
What else is on the label?
Other ingredients: S-Adensoyl Methionine, Microcrystalline Cellulose, Magnesium Stearate, Talc, Metocrylic Copolymer.
How many labels does SAM-e 400 mg have?
One label is on file, entered on June 23, 2017.
- Label 74981 (current) Entered June 23, 2017 · on the market · 60 tablets
Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).
Who makes it?
The label names HBC Protocols, Inc. (manufacturer), Los Angeles, California. All HBC Protocols products.