PlainVitamins

Methyl-Guard Plus

by Thorne · capsule · 90 capsules

  • On the market (NIH)
  • UPC 6 93749 78901 7
  • DSLD label 291788
  • Serving 1 to 3 capsules; amounts per 3 capsules
  • 30 servings

Methyl-Guard Plus by Thorne lists 6 ingredients, 6 with an amount per serving of 3 capsules, such as 90 mg of riboflavin, 45 mg of vitamin B6, 5 mcg DFE of folate and 3 mg of vitamin B12. Its current label entered the NIH Dietary Supplement Label Database on July 18, 2023.

What is in Methyl-Guard Plus?

Each row as the label prints it, per serving of 3 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Methyl-Guard Plus: Supplement Facts rows against the market (DSLD label 291788, January 2026 release)
IngredientAmount% DVAmong products listing it
Riboflavinas Riboflavin 5'-Phosphate SodiumRiboflavin (Form: as Riboflavin 5'-Phosphate Sodium)90 mg6,923%Riboflavin in Methyl-Guard Plus against 9,824 products90 mg per serving; the middle half of products list 1.7 mg to 25 mg, the median 4 mg.DV 1.3 mg90 mg

Higher than 96% of 9,824 products listing riboflavin (median 4 mg).

Vitamin B6as Pyridoxal 5-PhosphateVitamin B6 (Form: as Pyridoxal 5'-Phosphate)45 mg2,647%Vitamin B6 in Methyl-Guard Plus against 15,277 products45 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg45 mg

Higher than 86% of 15,277 products listing vitamin B6 (median 6 mg).

Folate5 mcg DFE1,250%
L-5-Methyltetrahydrofolateas Glucosamine Salt, L-5-Methyltetrahydrofolic AcidL-5-Methyltetrahydrofolate (Form: from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) (Alt. Name: Quatrefolic)3 mg
Vitamin B12as MethylcobalaminVitamin B12 (Form: as Methylcobalamin)3 mg125,000%Vitamin B12 in Methyl-Guard Plus against 14,425 products3,000 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg3,000 mcg

Higher than 97% of 14,425 products listing vitamin B12 (median 36 mcg).

Betaine Anhydrousas Trimethylglycine1.8 gBetaine Anhydrous in Methyl-Guard Plus against 860 products1.8 g per serving; the middle half of products list 1 g to 2.5 g, the median 1.5 g.1.8 g

Higher than 51% of 860 products listing betaine anhydrous (median 1.5 g).

Source: NIH ODS Dietary Supplement Label Database, label 291788 (entered July 18, 2023), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • Its 90 mg of riboflavin is higher than 96% of the 9,824 riboflavin products that print an amount; 427 list more.
  • Its 3,000 mcg of vitamin B12 is higher than 97% of the 14,425 vitamin B12 products that print an amount; 326 list more.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

3 products list the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested use: Take 1-3 capsules daily or as recommended by your health-care practitioner.
Warnings
Tamper evident: Use only of bottle is sealed.
If pregnant, consult your health-care practitioner before using this product.
Allergens and what it does not contain
Gluten free
Storage
Store tightly sealed in a cool, dry place.

Source: label statements in DSLD label 291788.

What else is on the label?

Other ingredients: Hypromellose (derived from Cellulose) Capsule, Calcium Citrate, Calcium Laurate.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): Manufactured in the USA using US & imported ingredients.

How many labels does Methyl-Guard Plus have?

2 labels are on file under this name since December 22, 2019: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 291788 (current) Entered July 18, 2023 · on the market · 90 capsules · UPC 6 93749 78901 7
  2. Label 209562 Entered December 22, 2019 · off the market February 21, 2023 · 90 capsules · UPC 6 93749 78901 7

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Thorne Research, Inc. (manufacturer). All Thorne products.

Where next?