PlainVitamins

Methyl-Guard

by Thorne Research · capsule · 180 vegetarian capsules

  • Off the market since December 2017 (NIH)
  • UPC 6 93749 78703 7
  • DSLD label 16106
  • Serving 3 capsules
  • 60 servings

Methyl-Guard by Thorne Research lists 4 ingredients, 4 with an amount per serving of 3 capsules, such as 20.4 mg of vitamin B6, 1.2 mg of folate, 1.2 mg of vitamin B12 and 1.8 g of betaine anhydrous. Its current label entered the NIH Dietary Supplement Label Database on December 21, 2012.

What is in Methyl-Guard?

Each row as the label prints it, per serving of 3 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Methyl-Guard: Supplement Facts rows against the market (DSLD label 16106, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin B6as Pyridoxal 5-PhosphateVitamin B6 (Form: as Pyridoxal 5'-Phosphate)20.4 mg1,020%Vitamin B6 in Methyl-Guard against 15,277 products20.4 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg20.4 mg

Higher than 75% of 15,277 products listing vitamin B6 (median 6 mg). Per day at the most servings: 40.8 mg.

Folateas L-5-MethyltetrahydrofolateFolate (Form: as L-5-Methyltetrahydrofolate (Form: from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt))1.2 mg300%Folate in Methyl-Guard against 7,022 products1,200 mcg per serving; the middle half of products list 200 mcg to 400 mcg, the median 400 mcg.1,200 mcg

Higher than 97% of 7,022 products listing folate (median 400 mcg). Per day at the most servings: 2,400 mcg.

Vitamin B12as MethylcobalaminVitamin B12 (Form: as Methylcobalamin)1.2 mg20,000%Vitamin B12 in Methyl-Guard against 14,425 products1,200 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg1,200 mcg

Higher than 95% of 14,425 products listing vitamin B12 (median 36 mcg). Per day at the most servings: 2,400 mcg.

Betaine Anhydrousas Trimethylglycine1.8 gBetaine Anhydrous in Methyl-Guard against 860 products1.8 g per serving; the middle half of products list 1 g to 2.5 g, the median 1.5 g.1.8 g

Higher than 51% of 860 products listing betaine anhydrous (median 1.5 g). Per day at the most servings: 3.6 g.

Source: NIH ODS Dietary Supplement Label Database, label 16106 (entered December 21, 2012), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • Its 1,200 mcg of folate is higher than 97% of the 7,022 folate products that print an amount; 166 list more.
  • Its 1,200 mcg of vitamin B12 is higher than 95% of the 14,425 vitamin B12 products that print an amount; 682 list more.

The NIH database records 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

2 products list the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested Use: Take 3 capsules two times daily or as recommended by your health-care practitioner.
Warnings
If pregnant, consult your health-care practitioner before using this product.
Storage
Store tightly sealed in a cool, dry place.

Source: label statements in DSLD label 16106.

What else is on the label?

Other ingredients: Hypromellose (derived from Cellulose) Capsule, Calcium Citrate Laurate, Silicon Dioxide.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): (image)(R)HYPOALLERGENIC.

How many labels does Methyl-Guard have?

One label is on file, entered on December 21, 2012.

  1. Label 16106 (current) Entered December 21, 2012 · off the market December 5, 2017 · 180 vegetarian capsules · UPC 6 93749 78703 7

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Thorne Research, Inc. (manufacturer), Dover, Idaho. All Thorne Research products.

Where next?