PlainVitamins

MTHFR Renew

by Physician Designed · capsule · 60 capsules

  • On the market (NIH)
  • UPC 6 07111 48199 7
  • DSLD label 249575
  • Serving 2 capsules
  • 30 servings

MTHFR Renew by Physician Designed lists 11 ingredients, 11 with an amount per serving of 2 capsules, such as 50 mg of vitamin B6, 1,000 mcg of folate, 500 mcg of vitamin B12 and 50 mg of pantothenic acid. Its current label entered the NIH Dietary Supplement Label Database on August 23, 2021.

What is in MTHFR Renew?

Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

MTHFR Renew: Supplement Facts rows against the market (DSLD label 249575, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin B6as Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride50 mg2,941%Vitamin B6 in MTHFR Renew against 15,277 products50 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg50 mg

Higher than 87% of 15,277 products listing vitamin B6 (median 6 mg).

Folateas Calcium 5-Methyltetrahydrofolate1,000 mcg250%Folate in MTHFR Renew against 7,022 products1,000 mcg per serving; the middle half of products list 200 mcg to 400 mcg, the median 400 mcg.1,000 mcg

Higher than 93% of 7,022 products listing folate (median 400 mcg).

Vitamin B12as MethylcobalaminVitamin B12 (Form: as Methylcobalamin)500 mcg20,833%Vitamin B12 in MTHFR Renew against 14,425 products500 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg500 mcg

Higher than 82% of 14,425 products listing vitamin B12 (median 36 mcg).

Pantothenic Acidas D-Calcium PantothenatePantothenic Acid (Form: as D-Calcium Pantothenate)50 mg1,000%Pantothenic Acid (Vitamin B5) in MTHFR Renew against 10,060 products50 mg per serving; the middle half of products list 6 mg to 50 mg, the median 12 mg.DV 5 mg50 mg

Higher than 72% of 10,060 products listing pantothenic acid (vitamin B5) (median 12 mg).

Zincas Zinc Amino Acid ChelateZinc (Form: as Zinc Amino Acid Chelate)5 mg45%Zinc in MTHFR Renew against 13,186 products5 mg per serving; the middle half of products list 5 mg to 15 mg, the median 11 mg.DV 11 mgUL 40 mg5 mg

72% of 13,186 products listing zinc give more (median 11 mg).

Choline Bitartrate50 mg9%*Choline in MTHFR Renew against 4,738 products50 mg per serving; the middle half of products list 18 mg to 100 mg, the median 40 mg.DV 550 mgUL 3,500 mg50 mg

Higher than 54% of 4,738 products listing choline (median 40 mg).

N-Acetyl L-Cysteine100 mgN-Acetyl Cysteine in MTHFR Renew against 1,259 products100 mg per serving; the middle half of products list 55 mg to 500 mg, the median 150 mg.100 mg

57% of 1,259 products listing N-acetyl cysteine give more (median 150 mg).

Betaine Anhydrous80 mgBetaine Anhydrous in MTHFR Renew against 860 products0.08 g per serving; the middle half of products list 1 g to 2.5 g, the median 1.5 g.0.08 g

92% of 860 products listing betaine anhydrous give more (median 1.5 g).

N-Acetyl L-Tyrosine50 mgN-Acetyl Tyrosine in MTHFR Renew against 344 products50 mg per serving; the middle half of products list 100 mg to 500 mg, the median 250 mg.50 mg

85% of 344 products listing N-acetyl tyrosine give more (median 250 mg).

Serine50 mgSerine in MTHFR Renew against 314 products50 mg per serving; the middle half of products list 100 mg to 1,056 mg, the median 408 mg.50 mg

85% of 314 products listing serine give more (median 408 mg).

L-Glutamine25 mgGlutamine in MTHFR Renew against 1,850 products0.025 g per serving; the middle half of products list 0.356 g to 3 g, the median 1 g.0.025 g

96% of 1,850 products listing glutamine give more (median 1 g).

* % Daily Value computed from the printed amount and the FDA Daily Value (21 CFR 101.9); the label prints none for that row.

Source: NIH ODS Dietary Supplement Label Database, label 249575 (entered August 23, 2021), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • Its 1,000 mcg of folate is higher than 93% of the 7,022 folate products that print an amount; 183 list more.
  • 92% of the 860 products that print an amount of betaine anhydrous list more than its 0.08 g of betaine anhydrous (median 1.5 g).
  • 85% of the 344 products that print an amount of N-acetyl tyrosine list more than its 50 mg of N-acetyl L-tyrosine (filed by NIH under N-acetyl tyrosine) (median 250 mg).
  • 96% of the 1,850 products that print an amount of glutamine list more than its 0.025 g of L-glutamine (filed by NIH under glutamine) (median 1 g).

The NIH database records 0.5 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with MTHFR Renew's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested Use: As a dietary supplement, take one capsule daily, or as directed by a physician.
Warnings
Tamper evident. Do not use if seal is broken.
Keep out of reach of children.
Storage
Store in a cool, dry place.

Source: label statements in DSLD label 249575.

What else is on the label?

Other ingredients: Rice Flour, Natural flavor, Vegetable Capsules, Vegetable Magnesium Stearate.

How many labels does MTHFR Renew have?

One label is on file, entered on August 23, 2021.

  1. Label 249575 (current) Entered August 23, 2021 · on the market · 60 capsules · UPC 6 07111 48199 7

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Professional Nutraceutical Design (manufacturer), Lindon, UT. All Physician Designed products.

Where next?