PlainVitamins

MTHFR Endure

by Physician Designed · capsule · 60 capsules

  • On the market (NIH)
  • UPC 0 607111 482000
  • DSLD label 249573
  • Serving 2 capsules
  • 30 servings

MTHFR Endure by Physician Designed lists 10 ingredients, 10 with an amount per serving of 2 capsules, such as 25 mg of vitamin B6, 100 mcg DFE of folate, 1,000 mcg of vitamin B12 and 125 mg of pantothenic acid. Its current label entered the NIH Dietary Supplement Label Database on August 23, 2021.

What is in MTHFR Endure?

Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

MTHFR Endure: Supplement Facts rows against the market (DSLD label 249573, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin B6as Pyridoxine HydrochlorideVitamin B6 (Form: as Pyridoxine HCl)25 mg1,471%Vitamin B6 in MTHFR Endure against 15,277 products25 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg25 mg

Higher than 76% of 15,277 products listing vitamin B6 (median 6 mg).

Folateas Calcium 5-Methyltetrahydrofolate100 mcg DFE25%
Vitamin B12as HydroxocobalaminVitamin B12 (Form: as Hydroxocobalamin)1,000 mcg41,667%Vitamin B12 in MTHFR Endure against 14,425 products1,000 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg1,000 mcg

Higher than 89% of 14,425 products listing vitamin B12 (median 36 mcg).

Pantothenic Acidas Vitamin B5125 mg2,500%Pantothenic Acid (Vitamin B5) in MTHFR Endure against 10,060 products125 mg per serving; the middle half of products list 6 mg to 50 mg, the median 12 mg.DV 5 mg125 mg

Higher than 92% of 10,060 products listing pantothenic acid (vitamin B5) (median 12 mg).

Cholineas Choline BitartrateCholine (Form: as Choline Bitartrate)25 mg5%Choline in MTHFR Endure against 4,738 products25 mg per serving; the middle half of products list 18 mg to 100 mg, the median 40 mg.DV 550 mgUL 3,500 mg25 mg

59% of 4,738 products listing choline give more (median 40 mg).

Zincas Zinc Amino Acid ChelateZinc (Form: as Zinc AAC)5 mg45%Zinc in MTHFR Endure against 13,186 products5 mg per serving; the middle half of products list 5 mg to 15 mg, the median 11 mg.DV 11 mgUL 40 mg5 mg

72% of 13,186 products listing zinc give more (median 11 mg).

N-Acetyl L-Cysteine100 mgN-Acetyl Cysteine in MTHFR Endure against 1,259 products100 mg per serving; the middle half of products list 55 mg to 500 mg, the median 150 mg.100 mg

57% of 1,259 products listing N-acetyl cysteine give more (median 150 mg).

Betaine Anhydrous80 mgBetaine Anhydrous in MTHFR Endure against 860 products0.08 g per serving; the middle half of products list 1 g to 2.5 g, the median 1.5 g.0.08 g

92% of 860 products listing betaine anhydrous give more (median 1.5 g).

N-Acetyl L-Tyrosine50 mgN-Acetyl Tyrosine in MTHFR Endure against 344 products50 mg per serving; the middle half of products list 100 mg to 500 mg, the median 250 mg.50 mg

85% of 344 products listing N-acetyl tyrosine give more (median 250 mg).

L-Serine50 mgSerine in MTHFR Endure against 314 products50 mg per serving; the middle half of products list 100 mg to 1,056 mg, the median 408 mg.50 mg

85% of 314 products listing serine give more (median 408 mg).

Source: NIH ODS Dietary Supplement Label Database, label 249573 (entered August 23, 2021), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • Its 125 mg of pantothenic acid (vitamin B5) is higher than 92% of the 10,060 pantothenic acid (vitamin B5) products that print an amount; 724 list more.
  • 92% of the 860 products that print an amount of betaine anhydrous list more than its 0.08 g of betaine anhydrous (median 1.5 g).
  • 85% of the 344 products that print an amount of N-acetyl tyrosine list more than its 50 mg of N-acetyl L-tyrosine (filed by NIH under N-acetyl tyrosine) (median 250 mg).

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

1 product lists the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested Use: As a dietary supplement, take one capsule daily, or as directed by a physician.
Warnings
Tamper evident. Do not use if seal is broken.
Keep out of reach of children.
Storage
Store in a cool, dry place.

Source: label statements in DSLD label 249573.

What else is on the label?

Other ingredients: Rice Flour, Natural flavor, Vegetable Capsules, Vegetable Magnesium Stearate.

How many labels does MTHFR Endure have?

One label is on file, entered on August 23, 2021.

  1. Label 249573 (current) Entered August 23, 2021 · on the market · 60 capsules · UPC 0 607111 482000

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Professional Nutraceutical Design (manufacturer), Pleasant Grove, UT. All Physician Designed products.

Where next?