MethylAssist

by Pure Encapsulations · capsule · 90 capsules

  • On the market (NIH)
  • UPC 7 66298 11495 8
  • DSLD label 277776
  • Serving 1 capsule
  • 90 servings

MethylAssist by Pure Encapsulations lists 5 ingredients, 5 with an amount per serving of 1 capsule, such as 16 mg of vitamin B6, 1,667 mcg DFE of folate, 1,000 mcg of vitamin B12 and 75 mg of BenfoPure benfotiamine. Its current label entered the NIH Dietary Supplement Label Database on November 22, 2022.

What is in MethylAssist?

Each row as the label prints it, per serving of 1 capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

MethylAssist: Supplement Facts rows against the market (DSLD label 277776, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin B6as Pyridoxal 5-PhosphateVitamin B6 (Form: as Pyridoxal 5' Phosphate (Form: activated B6))16 mg941%Vitamin B6 in MethylAssist against 15,277 products16 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg16 mg

Higher than 70% of 15,277 products listing vitamin B6 (median 6 mg).

Folateas MetafolinFolate (Form: as Metafolin (Form: L-5-MTHF))1,667 mcg DFE417%
L-5-Mthf1,000 mcg
Vitamin B12as MethylcobalaminVitamin B12 (Form: as Methylcobalamin)1,000 mcg41,667%Vitamin B12 in MethylAssist against 14,425 products1,000 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg1,000 mcg

Higher than 89% of 14,425 products listing vitamin B12 (median 36 mcg).

BenfoPure Benfotiamine75 mgBenfotiamine in MethylAssist against 155 products75 mg per serving; the middle half of products list 50 mg to 200 mg, the median 150 mg.75 mg

59% of 155 products listing benfotiamine give more (median 150 mg).

Source: NIH ODS Dietary Supplement Label Database, label 277776 (entered November 22, 2022), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with MethylAssist's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Recommendations: As a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.
Warnings
Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children.
Use only if safety seal is intact.
Allergens and what it does not contain
Gluten-free, Non-GMO & Hypoallergenic
Storage
Store in a cool, dry place.

Source: label statements in DSLD label 277776.

What else is on the label?

Other ingredients: hypoallergenic Plant Fiber, Vegetarian Capsule.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): GFCO.org Certified gluten-free by the gluten-free certification organization, www.gluten.org. Listed with: Certified gluten-free (GFCO) (a seal is the label's claim; the certifier's own list confirms it).

How many labels does MethylAssist have?

3 labels are on file under this name since January 7, 2019: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 277776 (current) Entered November 22, 2022 · on the market · 90 capsules · UPC 7 66298 11495 8
  2. Label 204690 Entered July 24, 2019 · off the market March 22, 2022 · 90 capsules · UPC 7 66298 11495 8
  3. Label 184621 Entered January 7, 2019 · off the market May 31, 2018 · 90 capsules · UPC 7 66298 11495 8

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Pure Encapsulations (manufacturer), Sudbury, MA. All Pure Encapsulations products.

Where next?