PlainVitamins

Methyl-Plex B

by NuMedica · capsule · 60 vegetable capsules

  • On the market (NIH)
  • UPC 8 12527 01076 5
  • DSLD label 323580
  • Serving 1 capsule
  • 60 servings

Methyl-Plex B by NuMedica lists 7 ingredients, 7 with an amount per serving of 1 capsule, such as 25 mg of riboflavin, 25 mg of vitamin B6, 2,040 mcg DFE of folate and 1,000 mcg of vitamin B12. Its current label entered the NIH Dietary Supplement Label Database on January 23, 2025.

What is in Methyl-Plex B?

Each row as the label prints it, per serving of 1 capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Methyl-Plex B: Supplement Facts rows against the market (DSLD label 323580, January 2026 release)
IngredientAmount% DVAmong products listing it
Riboflavinas Riboflavin 5-Phosphate, Vitamin B225 mg1,923%Riboflavin in Methyl-Plex B against 9,824 products25 mg per serving; the middle half of products list 1.7 mg to 25 mg, the median 4 mg.DV 1.3 mg25 mg

Higher than 75% of 9,824 products listing riboflavin (median 4 mg).

Vitamin B6as Pyridoxal 5-Phosphate25 mg1,471%Vitamin B6 in Methyl-Plex B against 15,277 products25 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg25 mg

Higher than 76% of 15,277 products listing vitamin B6 (median 6 mg).

Folate2,040 mcg DFE510%
Quatrefolicas (6S)-5-Methyltetrahydrofolic Acid Glucosamine Salt600 mcg5-methyltetrahydrofolate glucosamine in Methyl-Plex B against 176 products600 mcg per serving; the middle half of products list 300 mcg to 800 mcg, the median 593 mcg.600 mcg

Higher than 50% of 176 products listing 5-methyltetrahydrofolate glucosamine (median 593 mcg).

(6S)-5-Methyltetrahydrofolic Acid, Calcium Salt600 mcg
Vitamin B12as Methylcobalamin1,000 mcg41,667%Vitamin B12 in Methyl-Plex B against 14,425 products1,000 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg1,000 mcg

Higher than 89% of 14,425 products listing vitamin B12 (median 36 mcg).

Trimethylglycineas Anhydrous Betaine500 mgBetaine in Methyl-Plex B against 731 products500 mg per serving; the middle half of products list 50 mg to 1,250 mg, the median 250 mg.500 mg

Higher than 55% of 731 products listing betaine (median 250 mg).

Source: NIH ODS Dietary Supplement Label Database, label 323580 (entered January 23, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

2 products list the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: Take one capsule once per day with a meal or as directed by your healthcare practitioner.
Warnings
Caution: Keep out of reach of children.
Allergens and what it does not contain
Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy. Sourced from non-GMO ingredients.
GF Gluten-Free
Storage
Storage: Keep tightly closed in a cool, dry place

Source: label statements in DSLD label 323580.

What else is on the label?

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): cGMP Third-Party Certified Facility.

How many labels does Methyl-Plex B have?

3 labels are on file under this name since August 31, 2018: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 323580 (current) Entered January 23, 2025 · on the market · 60 vegetable capsules · UPC 8 12527 01076 5
  2. Label 213619 Entered February 26, 2020 · off the market May 30, 2023 · 60 vegetable capsules · UPC 8 12527 01076 5
  3. Label 180186 Entered August 31, 2018 · off the market November 5, 2019 · 60 vegetable capsules · UPC 8 12527 01076 5

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names NuMedica LLC (distributor), Tulsa, OK. All NuMedica products.

Where next?