Ligaplex II

by SP Standard Process · capsule · 150 capsules

  • On the market (NIH)
  • UPC 8 12122 01120 4
  • DSLD label 340257
  • Serving 2 capsules
  • 75 servings

Ligaplex II by SP Standard Process lists 31 ingredients, 5 with an amount per serving of 2 capsules, such as 180 mcg RAE of vitamin A, 0.6 mcg (24 IU) of vitamin D, 0.7 mg of vitamin E and 2 mcg of vitamin B12; 26 sit inside a blend without their own amounts, beside 1 Nutrition Facts row (calories, fat and the like). Its current label entered the NIH Dietary Supplement Label Database on September 25, 2025.

What is in Ligaplex II?

Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Ligaplex II: Supplement Facts rows against the market (DSLD label 340257, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin A180 mcg RAE20%
Vitamin D0.6 mcg (24 IU)3%Vitamin D in Ligaplex II against 14,175 products0.6 mcg per serving; the middle half of products list 10 mcg to 25 mcg, the median 15 mcg.DV 20 mcgUL 100 mcg0.6 mcg

over 99% of 14,175 products listing vitamin D give more (median 15 mcg). Per day at the most servings: 1.2 mcg.

Vitamin E0.7 mg5%
Vitamin B122 mcg83%Vitamin B12 in Ligaplex II against 14,425 products2 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg2 mcg

93% of 14,425 products listing vitamin B12 give more (median 36 mcg). Per day at the most servings: 4 mcg.

Manganese35 mg1,522%Manganese in Ligaplex II against 7,016 products35 mg per serving; the middle half of products list 1 mg to 3.92 mg, the median 2 mg.DV 2.3 mgUL 11 mg35 mg

Higher than over 99% of 7,016 products listing manganese (median 2 mg). Per day at the most servings: 70 mg. 6.4 times the adult UL a day.

Sodium10 mg1%Sodium in Ligaplex II against 14,514 products10 mg per serving; the middle half of products list 15 mg to 142 mg, the median 55 mg.10 mg

78% of 14,514 products listing sodium give more (median 55 mg). Per day at the most servings: 20 mg.

Proprietary Blend650 mg
Nutritional Yeastin the blend, no amount given
Carbamidein the blend, no amount given
Bovine Bonein the blend, no amount given
Veal Bone PMG extractin the blend, no amount given
Bovine Liverin the blend, no amount given
Wheat Germ, Defattedin the blend, no amount given
Bovine Heart PMG extractin the blend, no amount given
Magnesium Citratein the blend, no amount given

The label names the compound (Magnesium Citrate); its amount is likely the compound's weight, not the magnesium it holds, so it is not placed among other products.

Oat Flourorganicin the blend, no amount given
Inositolin the blend, no amount given
organic Pea vine juice powderin the blend, no amount given
Spanish Mossin the blend, no amount given
organic Beetin the blend, no amount given
organic Sweet Potatoin the blend, no amount given
organic Carrotin the blend, no amount given
Ribonucleic Acidin the blend, no amount given
Bovine Liver Fat extractin the blend, no amount given
Bovine Adrenal Cytosol extractin the blend, no amount given
Bovine Kidneyin the blend, no amount given
Bovine Spleenin the blend, no amount given
Ovine Spleenin the blend, no amount given
organic Shiitake Mushroom powderin the blend, no amount given
organic Reishi Mushroom powderin the blend, no amount given
Rice Branin the blend, no amount given
Sunflower Lecithin powderin the blend, no amount given
Flaxseed Oilorganicin the blend, no amount given

Source: NIH ODS Dietary Supplement Label Database, label 340257 (entered September 25, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • over 99% of the 14,175 products that print an amount of vitamin D list more than its 0.6 mcg (24 IU) of vitamin D (median 15 mcg (600 IU)).
  • 93% of the 14,425 products that print an amount of vitamin B12 list more than its 2 mcg of vitamin B12 (median 36 mcg).
  • At 2 servings a day, the most its directions give, the label lists 70 mg of manganese, 6.4 times the adult Tolerable Upper Intake Level.

The NIH database records 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Ligaplex II's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested Use: Two capsules twice per day, or as directed.
Warnings
Warning: If you are pregnant, nursing or have impaired liver function, consult your health care professional before using this product.
Keep out of reach of children.
Contains: Wheat.

Source: label statements in DSLD label 340257.

What else is on the label?

Other ingredients: Manganese Glycerophosphate, Calcium Lactate, Gelatin, Water, Calcium Stearate, Ascorbic Acid, D-Alpha Tocopherol, Modified Corn Starch, Dicalcium Phosphate, modified Tapioca Starch, Vitamin A Palmitate, Sucrose, Cholecalciferol, Cyanocobalamin.

How many labels does Ligaplex II have?

4 labels are on file under this name since October 25, 2013: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 340257 (current) Entered September 25, 2025 · on the market · 150 capsules · UPC 8 12122 01120 4
  2. Label 256327 Entered November 19, 2021 · off the market August 15, 2025 · 150 capsules · UPC 8 12122 01120 4
  3. Label 207464 Entered September 24, 2019 · off the market July 6, 2021 · 150 capsules · UPC 8 12122 01120 4
  4. Label 26981 Entered October 25, 2013 · off the market July 10, 2017 · 150 capsules · UPC 8 12122 01120 4

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Standard Process Inc. (manufacturer), Palmyra, WI. All SP Standard Process products.

Where next?