PlainVitamins

Homocysteine Factors

by Pure Encapsulations · capsule · 180 capsules

  • On the market (NIH)
  • UPC 7 66298 00152 4
  • DSLD label 295516
  • Serving 1 capsule
  • 180 servings

Homocysteine Factors by Pure Encapsulations lists 5 ingredients, 5 with an amount per serving of 1 capsule, such as 25 mcg of vitamin B6, 667 mcg DFE of folate, 200 mcg of vitamin B12 and 500 mg of trimethylglycine. Its current label entered the NIH Dietary Supplement Label Database on July 18, 2023.

What is in Homocysteine Factors?

Each row as the label prints it, per serving of 1 capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Homocysteine Factors: Supplement Facts rows against the market (DSLD label 295516, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin B6as Pyridoxal 5-Phosphate25 mcg1,471%

This amount is far outside what other labels list for vitamin B6, or disagrees with the label's own %DV: possibly a unit or transcription slip in the database. Check the label image on DSLD.

Folateas Metafolin667 mcg DFE167%
L-5-Methyltetrahydrofolate400 mcg
Vitamin B12as Methylcobalamin200 mcg8,333%Vitamin B12 in Homocysteine Factors against 14,425 products200 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg200 mcg

Higher than 74% of 14,425 products listing vitamin B12 (median 36 mcg). Per day at the most servings: 400 mcg.

Trimethylglycineas Anhydrous Betaine500 mgBetaine in Homocysteine Factors against 731 products500 mg per serving; the middle half of products list 50 mg to 1,250 mg, the median 250 mg.500 mg

Higher than 55% of 731 products listing betaine (median 250 mg). Per day at the most servings: 1,000 mg.

Source: NIH ODS Dietary Supplement Label Database, label 295516 (entered July 18, 2023), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.

The NIH database records 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

6 products list the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Recommendations: As a dietary supplement, take 1 capsule, 2 times daily, with meals.
Warnings
Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children.
Use only if safety seal is intact.
Gluten-free, non-GMO & hypoallergenic
Allergens and what it does not contain
Certified Gluten-free by the Gluten-Free Certification Organization, www.gluten.org
Storage
Refrigerate after opening.

Source: label statements in DSLD label 295516.

What else is on the label?

Other ingredients: Vegetarian Capsule, hypoallergenic Plant Fiber, Ascorbyl Palmitate.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): GFCO.org (Gluten-Free Certification Organization). Listed with: Certified gluten-free (GFCO) (a seal is the label's claim; the certifier's own list confirms it).

How many labels does Homocysteine Factors have?

9 labels are on file under this name since January 7, 2019: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 295516 (current) Entered July 18, 2023 · on the market · 180 capsules · UPC 7 66298 00152 4
  2. Label 293972 Entered July 18, 2023 · on the market · 60 capsules · UPC 7 66298 00151 7
  3. Label 246141 Entered June 23, 2021 · off the market July 21, 2022 · 60 capsules · UPC 7 66298 00151 7
  4. Label 246140 Entered March 25, 2021 · off the market July 21, 2022 · 180 capsules · UPC 7 66298 00152 4
  5. Label 219083 Entered June 24, 2020 · off the market November 21, 2018 · 180 capsules · UPC 7 66298 00152 4
  6. Label 219080 Entered April 23, 2020 · off the market December 6, 2018 · 60 capsules · UPC 7 66298 00151 7
  7. Label 204595 Entered July 24, 2019 · off the market December 16, 2020 · 180 capsules · UPC 7 66298 00152 4
  8. Label 184329 Entered February 25, 2019 · off the market May 31, 2018 · 180 capsules · UPC 7 66298 00152 4
  9. Label 184984 Entered January 7, 2019 · off the market December 16, 2020 · 60 capsules · UPC 7 66298 00151 7

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Pure Encapsulations (manufacturer), Sudbury, MA. All Pure Encapsulations products.

Where next?