PlainVitamins

non-nutrient/non-botanical

Methylsulfonylmethane supplements

Half of the 1,454 methylsulfonylmethane supplements in the NIH label database that print an amount list 500 mg or less per serving; the middle half list 150 mg to 1,000 mg (DSLD version 9.4.0, January 2026). The 174 products whose only supplement ingredient is methylsulfonylmethane list a median of 1,000 mg.

Products listing it
1,8411,454 print an amount; 385 list it inside a blend without an amount
Median per serving
500 mgmiddle half 150 mg to 1,000 mg

How much methylsulfonylmethane do supplements contain?

The median product lists 500 mg per serving. One in ten lists 50 mg or less, one in ten 1,500 mg or more. The amount printed most often is 500 mg (208 products).

Products by amount of methylsulfonylmethane per serving

1,454 products, log scale; extreme 0.2% at each end left out of the drawing.

Methylsulfonylmethane: products by amount per serving3 mg10 mg100 mg1,000 mg
Methylsulfonylmethane: products by amount per serving3 mg10 mg30 mg100 mg300 mg1,000 mg
Methylsulfonylmethane: products by amount per serving3 mg10 mg30 mg100 mg300 mg1,000 mg3,000 mg
Methylsulfonylmethane: products by amount per serving3 mg10 mg30 mg100 mg300 mg1,000 mg3,000 mg
Methylsulfonylmethane: products by amount per serving3 mg10 mg30 mg100 mg300 mg1,000 mg3,000 mg
The amounts printed most often
Amount per servingProductsFor example
500 mg208 SAM-e (GNC TriFlex); MSM & Glucosamine (Nature's Bounty); Joint Movement Glucosamine Natural Berry Flavor (Wellesse)
1,000 mg179 MSM 1000 mg (Vitamin World); Maximum Strength Glucosamine MSM Complex (Nature's Bounty); Mercury Amalgam Formula (Douglas Laboratories)
100 mg131 Pain RX (Vitabase); ProtoClear Detoxification Formula (Protocol For Life Balance); ProtoClear Natural Orange Flavor (Protocol For Life Balance)
250 mg104 Super Joint Formula (Vitabase); Prostate Formula (Vitabase); Ultra Glucosamine + MSM (The Professional Series)
1,500 mg87 MSM (MethylSulfonylMethane) 1,500 mg (Bronson); Joint Support Glucosamine Chondroitin Plus MSM with Univestin (Kroger); Glucosamine Chondroitin Complex plus MSM (up&up)
200 mg67 Nails (Viva Vitamins); Glucosamine, Chondroitin & MSM (Doctor's A-Z); GluComplex Gold (SimplyBest)
300 mg63 Joint Relief Complex II (Healthy Choice Naturals); Glucosamine & Chondroitin Plus MSM (NOW); Celadrin & MSM 500 mg (NOW)
750 mg63 Glucosamine HCl & MSM Triple Strength (Sunmark); Joint Health Pack (Douglas Laboratories); Glucosamine, Chondroitin And MSM (Rugby)
25 mg57 Mega Vita Woman 50+ High Potency (Vitamin World); Ultra Vita Man 50+ (Vitamin World); PediaFocus - DF Natural Vanilla Flavor (Designs for Health)
50 mg44 LifeEssence (Pure Essence Labs); Great Hair (Vitabase); A/ O Maximizers (Douglas Laboratories)

Source: Supplement Facts rows of every product's current label, NIH ODS Dietary Supplement Label Database version 9.4.0; amounts in one measure (weight).

Which products list the most methylsulfonylmethane?

On-market products, per serving, with a plausible amount: the rule leaves out likely entry slips, such as an amount far beyond every other label with no %DV or strength on the label to back it (each product page still shows its own amount, marked).

Have the amounts changed over the years?

Products whose current label entered DSLD in 2011 list a median of 500 mg; those entered in 2025, 260 mg.

Median methylsulfonylmethane per serving by the year the label entered DSLD (years with 20+ products)
YearProductsMedian per serving
201127500 mg
201296500 mg
201395500 mg
201457500 mg
201572300 mg
201669500 mg
201790316.5 mg
201858362.5 mg
201970450 mg
2020133500 mg
2021113400 mg
2022151500 mg
2023122500 mg
2024177400 mg
2025124260 mg

Source: DSLD label entry dates and amounts, current labels.

In which products and brands?

Products listing methylsulfonylmethane by DSLD product type

Methylsulfonylmethane by product typeOther Combinations1,137Non-Nutrient/Non-Botanical306Botanical with Nutrients5Botanical4Amino acid/Protein1Mineral1
Methylsulfonylmethane by product typeOther Combinations1,137Non-Nutrient/Non-Botanical306Botanical with Nutrients5Botanical4Amino acid/Protein1Mineral1
Methylsulfonylmethane by product typeOther Combinations1,137Non-Nutrient/Non-Botanical306Botanical with Nutrients5Botanical4Amino acid/Protein1Mineral1
Methylsulfonylmethane by product typeOther Combinations1,137Non-Nutrient/Non-Botanical306Botanical with Nutrients5Botanical4Amino acid/Protein1Mineral1
Methylsulfonylmethane by product typeOther Combinations1,137Non-Nutrient/Non-Botanical306Botanical with Nutrients5Botanical4Amino acid/Protein1Mineral1

Brands listing it most: NOW (24), Nature's Plus (22), Douglas Laboratories (18), NewtonEverett (18), XYMOGEN (17), Wonder Laboratories (16), Doctor's Best (16), Source Naturals (15), DC (15), Xtendlife (14).

Every product listing methylsulfonylmethane

1,841 products, A to Z by name (page 10 of 37), each with the amount its label prints; an amount far outside what other labels print is marked as a possible slip.

Where next?