PlainVitamins

Stress-Defy

by Irwin Naturals · softgel capsule · 84 liquid softgels

  • On the market (NIH)
  • UPC 7 10363 56821 4
  • DSLD label 323295
  • Serving 2 liquid softgels
  • 42 servings

Stress-Defy by Irwin Naturals lists 14 ingredients, 14 with an amount per serving of 2 liquid softgels, such as 26 mg of thiamine, 26 mg of riboflavin, 50 mg of vitamin B6 and 19 mg of calcium, beside 3 Nutrition Facts rows (calories, fat and the like). Its current label entered the NIH Dietary Supplement Label Database on January 23, 2025.

What is in Stress-Defy?

Each row as the label prints it, per serving of 2 liquid softgels. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Stress-Defy: Supplement Facts rows against the market (DSLD label 323295, January 2026 release)
IngredientAmount% DVAmong products listing it
Calories20 Calories
Total Fat1 g2%Fat (unspecified) in Stress-Defy against 11,965 products1 g per serving; the middle half of products list 1 g to 2.5 g, the median 1.5 g.1 g

56% of 11,965 products listing fat (unspecified) give more (median 1.5 g). Per day at the most servings: 2 g.

Total Carbohydrates1 g1%Carbohydrate in Stress-Defy against 21,979 products1 g per serving; the middle half of products list 1 g to 6 g, the median 3 g.1 g

74% of 21,979 products listing carbohydrate give more (median 3 g). Per day at the most servings: 2 g.

Protein1 gProtein in Stress-Defy against 8,985 products1 g per serving; the middle half of products list 2 g to 24 g, the median 16 g.1 g

77% of 8,985 products listing protein give more (median 16 g). Per day at the most servings: 2 g.

Thiamineas Thiamine Mononitrate26 mg2,167%Thiamin in Stress-Defy against 9,830 products26 mg per serving; the middle half of products list 1.5 mg to 25 mg, the median 5 mg.DV 1.2 mg26 mg

Higher than 78% of 9,830 products listing thiamin (median 5 mg). Per day at the most servings: 52 mg.

Riboflavin26 mg2,000%Riboflavin in Stress-Defy against 9,824 products26 mg per serving; the middle half of products list 1.7 mg to 25 mg, the median 4 mg.DV 1.3 mg26 mg

Higher than 82% of 9,824 products listing riboflavin (median 4 mg). Per day at the most servings: 52 mg.

Vitamin B6as Pyridoxine Hydrochloride50 mg2,941%Vitamin B6 in Stress-Defy against 15,277 products50 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg50 mg

Higher than 87% of 15,277 products listing vitamin B6 (median 6 mg). Per day at the most servings: 100 mg.

Calciumas Calcium Citrate19 mg1%Calcium in Stress-Defy against 17,831 products19 mg per serving; the middle half of products list 50 mg to 252 mg, the median 115 mg.DV 1,300 mgUL 2,500 mg19 mg

93% of 17,831 products listing calcium give more (median 115 mg). Per day at the most servings: 38 mg.

Magnesiumas Magnesium Citrate13 mg3%Magnesium in Stress-Defy against 14,003 products13 mg per serving; the middle half of products list 30 mg to 200 mg, the median 86 mg.UL 350 mgDV 420 mg13 mg

89% of 14,003 products listing magnesium give more (median 86 mg). Per day at the most servings: 26 mg.

Flaxseed Oil1,400 mgFlaxseed Oil in Stress-Defy against 512 products1.4 g per serving; the middle half of products list 0.4 g to 1.15 g, the median 1 g.1.4 g

Higher than 84% of 512 products listing flaxseed oil (median 1 g). Per day at the most servings: 2.8 g.

Chinese Skullcap root extract200 mgBaikal Skullcap in Stress-Defy against 114 products200 mg per serving; the middle half of products list 40 mg to 200 mg, the median 90 mg.200 mg

Higher than 67% of 114 products listing baikal skullcap (median 90 mg). Per day at the most servings: 400 mg.

Holy Basil Herb Extractas Ocimum tenuiflorum Herb Extract150 mgHoly Basil in Stress-Defy against 387 products150 mg per serving; the middle half of products list 50 mg to 400 mg, the median 129 mg.150 mg

Higher than 51% of 387 products listing holy basil (median 129 mg). Per day at the most servings: 300 mg.

Ginkgo Leaf Extract100 mgGinkgo in Stress-Defy against 1,339 products100 mg per serving; the middle half of products list 30 mg to 120 mg, the median 60 mg.100 mg

Higher than 59% of 1,339 products listing ginkgo (median 60 mg). Per day at the most servings: 200 mg.

L-Theanine100 mgTheanine in Stress-Defy against 1,602 products100 mg per serving; the middle half of products list 90 mg to 200 mg, the median 100 mg.100 mg

47% of 1,602 products listing theanine give more (median 100 mg). Per day at the most servings: 200 mg.

Rhodiola Root Extractas Rhodiola rosea Root Extract100 mgRhodiola in Stress-Defy against 945 products100 mg per serving; the middle half of products list 50 mg to 250 mg, the median 100 mg.100 mg

49% of 945 products listing rhodiola give more (median 100 mg). Per day at the most servings: 200 mg.

Rosavins1%1 mgRosavin in Stress-Defy against 72 products1 mg per serving; the middle half of products list 2.25 mg to 6 mg, the median 5.13 mg.1 mg

89% of 72 products listing rosavin give more (median 5.13 mg). Per day at the most servings: 2 mg.

Salidrosides1%1 mgSalidroside in Stress-Defy against 48 products1 mg per serving; the middle half of products list 0.938 mg to 4 mg, the median 1.9 mg.1 mg

58% of 48 products listing salidroside give more (median 1.9 mg). Per day at the most servings: 2 mg.

GABA60 mgGABA in Stress-Defy against 744 products60 mg per serving; the middle half of products list 80 mg to 400 mg, the median 100 mg.60 mg

76% of 744 products listing GABA give more (median 100 mg). Per day at the most servings: 120 mg.

BioPerine Complexas BioPerine, Ginger Rhizome Extract95% piperine, 5% gingerols3 mg

Source: NIH ODS Dietary Supplement Label Database, label 323295 (entered January 23, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • 93% of the 17,831 products that print an amount of calcium list more than its 19 mg of calcium (median 115 mg).
  • 89% of the 72 products that print an amount of rosavin list more than its 1 mg of rosavin (median 5.13 mg).

The NIH database records 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Stress-Defy's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Full disclosure ingredient panel Directions: (Adult) Take two (2) liquid soft-gels twice a day with meals and a full glass (8oz) of water.
Warnings
Usage warnings: Do not use if safety seal is broken. This product contains an ingredients that may affect blood sugar. Do not exceed recommended daily intake. Warning: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.
Check with your doctor if you are using medication, including anti-coagulants (blood thinners), or have any medical conditions, including heart disease or high/low blood pressure. Do not use if you may become pregnant, are pregnant or nursing.
Not intended for use by persons under 18. Keep out of reach of children.
Contains: Soy
Allergens and what it does not contain
No preservatives added.
Storage
Store in a cool, dry place.

Source: label statements in DSLD label 323295.

What else is on the label?

Other ingredients: Gelatin, Water, Purified, Glycerin, Soy Lecithin, Beeswax, Maltodextrin, Titanium Dioxide, Turmeric, Sodium Copper Chlorophyllin, Silicon Dioxide.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): Pass Quality Tested Guaranteed.

How many labels does Stress-Defy have?

5 labels are on file under this name since April 24, 2015: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 323295 (current) Entered January 23, 2025 · on the market · 84 liquid softgels · UPC 7 10363 56821 4
  2. Label 256446 Entered October 22, 2021 · off the market June 1, 2023 · 84 liquid softgels · UPC 7 10363 56821 4
  3. Label 56501 Entered February 23, 2016 · off the market July 7, 2021 · 84 liquid soft-gels · UPC 7 10363 56821 4
  4. Label 44851 Entered April 24, 2015 · off the market December 4, 2015 · 84 liquid soft-gels · UPC 7 10363 56821 4
  5. Label 44696 Entered April 24, 2015 · off the market March 25, 2015 · 84 liquid soft-gels · UPC 7 10363 56821 4

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Irwin Naturals (manufacturer, distributor), Los Angeles, CA. All Irwin Naturals products.

Where next?