High Potency Optimized Folate
by Life Extension · tablet or pill · 30 vegetarian tablets
- On the market (NIH)
- UPC 7 37870 19133 9
- DSLD label 74001
- Serving 1 vegetarian tablet
High Potency Optimized Folate by Life Extension lists one ingredient: 5,000 mcg of folate per serving of 1 vegetarian tablet. Its current label entered the NIH Dietary Supplement Label Database on May 24, 2017.
What is in High Potency Optimized Folate?
Each row as the label prints it, per serving of 1 vegetarian tablet. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).
| Ingredient | Amount | % DV | Among products listing it |
|---|---|---|---|
| Folateas (6S)-5-Methyltetrahydrofolate Calcium SaltFolate (Form: as (6S)-5-Methyltetrahydrofolate, Calcium Salt) | 5,000 mcg | 1,250% | Higher than 99% of 7,022 products listing folate (median 400 mcg). |
Source: NIH ODS Dietary Supplement Label Database, label 74001 (entered May 24, 2017), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.
Is that a lot?
The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:
- Its 5,000 mcg of folate is higher than 99% of the 7,022 folate products that print an amount; 71 list more.
The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.
The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.
Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.
Which products have the closest formulas?
6 products list the very same ingredients; the nearest amounts come first.
- Folic Acid Folate 5LifeLink same ingredients
- 5-MTHF 5 mgThorne Research · off the market same ingredients
- Methyl Folate L-5-MTHFDouglas Laboratories · off the market same ingredients
- High Potency Optimized Folate 5000 mcgLife Extension · off the market same ingredients
- L-Methylfolate Calcium 7.5 mgVirtus Pharmaceuticals same ingredients
- 5-MTHF 7.5 mgFresh Nutrition same ingredients
Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.
What does the label say about taking it?
Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.
- Directions
- Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.
- Warnings
- Caution: Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your personal physician.
- Warnings: Keep out of reach of children.
- Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
- Allergens and what it does not contain
- Non-GMO
- Storage
- Store tightly closed in a cool, dry place.
Source: label statements in DSLD label 74001.
What else is on the label?
Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Croscarmellose Sodium, Silica, Vegetable Stearate.
How many labels does High Potency Optimized Folate have?
2 labels are on file under this name since May 22, 2016: other sizes, label designs and reformulations. The current one leads this page.
- Label 74001 (current) Entered May 24, 2017 · on the market · 30 vegetarian tablets · UPC 7 37870 19133 9
- Label 59599 Entered May 22, 2016 · off the market April 26, 2017 · 30 vegetarian tablets · UPC 7 37870 19133 9
DSLD also links this label to: High Potency Optimized Folate 8500 mcg DFE (image difference, same product), High Potency Optimized Folate 5000 mcg (image difference, same product).
Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).
Who makes it?
The label names Quality Supplements and Vitamins, Inc. (distributor), Ft. Lauderdale, FL. All Life Extension products.