Bio-B12

by Thorne Research · capsule · 60 vegetarian capsules

  • Off the market since December 2019 (NIH)
  • UPC 6 93749 12003 2
  • DSLD label 63553
  • Serving 1 capsule

Bio-B12 by Thorne Research lists 4 ingredients, 4 with an amount per serving of 1 capsule, such as 1 mg of vitamin B12, 800 mcg of folate, 15 mg of zinc and 75 mg of papain. Its current label entered the NIH Dietary Supplement Label Database on August 24, 2016.

What is in Bio-B12?

Each row as the label prints it, per serving of 1 capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Bio-B12: Supplement Facts rows against the market (DSLD label 63553, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin B12as MethylcobalaminVitamin B12 (Form: as Methylcobalamin)1 mg16,667%Vitamin B12 in Bio-B12 against 14,425 products1,000 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg1,000 mcg

Higher than 89% of 14,425 products listing vitamin B12 (median 36 mcg). Per day at the most servings: 3,000 mcg.

Folateas L-5-MethyltetrahydrofolateFolate (Form: as L-5-Methyltetrahydrofolate (Form: from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt))800 mcg200%Folate in Bio-B12 against 7,022 products800 mcg per serving; the middle half of products list 200 mcg to 400 mcg, the median 400 mcg.800 mcg

Higher than 81% of 7,022 products listing folate (median 400 mcg). Per day at the most servings: 2,400 mcg.

Zincas Zinc PicolinateZinc (Form: as Zinc Picolinate)15 mg100%Zinc in Bio-B12 against 13,186 products15 mg per serving; the middle half of products list 5 mg to 15 mg, the median 11 mg.DV 11 mgUL 40 mg15 mg

Higher than 56% of 13,186 products listing zinc (median 11 mg). Per day at the most servings: 45 mg. 1.1 times the adult UL a day.

Papainas PapayaPapain (Form: an enzyme derived from Papaya Genus: Carica Species: papaya)75 mgPapain in Bio-B12 against 607 products75 mg per serving; the middle half of products list 20 mg to 75 mg, the median 40 mg.75 mg

Higher than 73% of 607 products listing papain (median 40 mg). Per day at the most servings: 225 mg.

Source: NIH ODS Dietary Supplement Label Database, label 63553 (entered August 24, 2016), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • At 3 servings a day, the most its directions give, the label lists 45 mg of zinc, 1.1 times the adult Tolerable Upper Intake Level.

The NIH database records 1 to 3 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Bio-B12's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested Use: Take 1 capsule one to three times daily or as recommended by your health-care practitioner.
Warnings
If pregnant, consult your health-care practitioner before using this product.
Tamper Evident: Use only if bottle is sealed.
Storage
Store tightly sealed in a cool, dry place.

Source: label statements in DSLD label 63553.

What else is on the label?

Other ingredients: Hypromellose (derived from Cellulose) Capsule, Microcrystalline Cellulose, Silicon Dioxide.

How many labels does Bio-B12 have?

2 labels are on file under this name since November 21, 2012: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 63553 (current) Entered August 24, 2016 · off the market December 18, 2019 · 60 vegetarian capsules · UPC 6 93749 12003 2
  2. Label 15704 Entered November 21, 2012 · off the market January 15, 2016 · 60 vegetarian capsules · UPC 6 93749 12003 2

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Thorne Research, Inc. (manufacturer), Dover, Idaho. All Thorne Research products.

Where next?