What the NIH DSLD Says About 21st Century

According to the U.S. National Institutes of Health's Dietary Supplement Label Database (DSLD), more than 175,000 dietary supplement product labels are catalogued across the U.S. retail and direct-sale supplement market in 2025. The DSLD is jointly maintained by the NIH Office of Dietary Supplements (ODS) and the U.S. National Library of Medicine (NLM), and reflects supplement label data as voluntarily submitted by manufacturers under the Dietary Supplement Health and Education Act of 1994 (DSHEA).

21st Century is cataloged in the NIH DSLD with 423 distinct product labels on file, 185 on-market and 238 off-market (44% active rate), a mix of currently marketed and discontinued products. See the product list below for individual labels, ingredients, and current marketing status.

The DSLD is updated continuously as new product labels are submitted to the NIH ODS for inclusion. Coverage extends across multivitamins, single-ingredient supplements, botanicals, mineral preparations, and specialty formulations. Brand catalogs vary widely in scope, large manufacturers may carry hundreds of label variants across formulations, dosage strengths, and packaging configurations, while smaller specialty brands typically maintain narrower portfolios. See our methodology page for full source attribution, refresh cadence, DSHEA regulatory scope, and the distinction between FDA-regulated drug labels and supplement labels.