PlainVitamins

System-Six

by Irwin Naturals · softgel capsule · 60 liquid softgels

  • On the market (NIH)
  • UPC 7 10363 59875 4
  • DSLD label 292134
  • Serving 3 liquid softgels
  • 20 servings

System-Six by Irwin Naturals lists 30 ingredients, 28 with an amount per serving of 3 liquid softgels, such as 8 mg of vitamin C, 4.5 mg of vitamin E, 0.5 mg of thiamine and 0.5 mg of riboflavin; 2 sit inside a blend without their own amounts, beside 4 Nutrition Facts rows (calories, fat and the like). Its current label entered the NIH Dietary Supplement Label Database on July 18, 2023.

What is in System-Six?

Each row as the label prints it, per serving of 3 liquid softgels. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

System-Six: Supplement Facts rows against the market (DSLD label 292134, January 2026 release)
IngredientAmount% DVAmong products listing it
Calories25 Calories
Total Fat1.5 g2%Fat (unspecified) in System-Six against 11,965 products1.5 g per serving; the middle half of products list 1 g to 2.5 g, the median 1.5 g.1.5 g

44% of 11,965 products listing fat (unspecified) give more (median 1.5 g). Per day at the most servings: 3 g.

Cholesterol5 mg2%Cholesterol in System-Six against 5,275 products5 mg per serving; the middle half of products list 5 mg to 45 mg, the median 15 mg.5 mg

71% of 5,275 products listing cholesterol give more (median 15 mg). Per day at the most servings: 10 mg.

Total Carbohydrates2 g1%Carbohydrate in System-Six against 21,979 products2 g per serving; the middle half of products list 1 g to 6 g, the median 3 g.2 g

58% of 21,979 products listing carbohydrate give more (median 3 g). Per day at the most servings: 4 g.

Protein2 gProtein in System-Six against 8,985 products2 g per serving; the middle half of products list 2 g to 24 g, the median 16 g.2 g

70% of 8,985 products listing protein give more (median 16 g). Per day at the most servings: 4 g.

Vitamin Cas Ascorbic Acid8 mg9%Vitamin C in System-Six against 18,583 products8 mg per serving; the middle half of products list 60 mg to 270 mg, the median 100 mg.DV 90 mgUL 2,000 mg8 mg

96% of 18,583 products listing vitamin C give more (median 100 mg). Per day at the most servings: 16 mg.

Vitamin Eas D-Alpha-Tocopherol4.5 mg30%
Thiamineas Thiamine Hydrochloride0.5 mg42%Thiamin in System-Six against 9,830 products0.5 mg per serving; the middle half of products list 1.5 mg to 25 mg, the median 5 mg.DV 1.2 mg0.5 mg

91% of 9,830 products listing thiamin give more (median 5 mg). Per day at the most servings: 1 mg.

Riboflavin0.5 mg38%Riboflavin in System-Six against 9,824 products0.5 mg per serving; the middle half of products list 1.7 mg to 25 mg, the median 4 mg.DV 1.3 mg0.5 mg

91% of 9,824 products listing riboflavin give more (median 4 mg). Per day at the most servings: 1 mg.

Niacinas Niacinamide7 mg44%Niacin in System-Six against 12,413 products7 mg per serving; the middle half of products list 13.2 mg to 48 mg, the median 20 mg.DV 16 mgUL 35 mg7 mg

87% of 12,413 products listing niacin give more (median 20 mg). Per day at the most servings: 14 mg.

Vitamin B12as Cyanocobalamin7 mcg292%Vitamin B12 in System-Six against 14,425 products7 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg7 mcg

74% of 14,425 products listing vitamin B12 give more (median 36 mcg). Per day at the most servings: 14 mcg.

Pantothenic Acidas D-Calcium Pantothenate15 mg300%Pantothenic Acid (Vitamin B5) in System-Six against 10,060 products15 mg per serving; the middle half of products list 6 mg to 50 mg, the median 12 mg.DV 5 mg15 mg

Higher than 51% of 10,060 products listing pantothenic acid (vitamin B5) (median 12 mg). Per day at the most servings: 30 mg.

Cholineas Choline Bitartrate20 mg3%Choline in System-Six against 4,738 products20 mg per serving; the middle half of products list 18 mg to 100 mg, the median 40 mg.DV 550 mgUL 3,500 mg20 mg

68% of 4,738 products listing choline give more (median 40 mg). Per day at the most servings: 40 mg.

Seleniumas Selenium Aspartate17 mcg31%Selenium in System-Six against 7,658 products17 mcg per serving; the middle half of products list 27 mcg to 100 mcg, the median 55 mcg.DV 55 mcgUL 400 mcg17 mcg

89% of 7,658 products listing selenium give more (median 55 mcg). Per day at the most servings: 34 mcg.

Chromiumas Chromium Picolinate100 mcg286%Chromium in System-Six against 7,825 products100 mcg per serving; the middle half of products list 45 mcg to 200 mcg, the median 100 mcg.DV 35 mcg100 mcg

47% of 7,825 products listing chromium give more (median 100 mcg). Per day at the most servings: 200 mcg.

Fish Oilas Anchovy, Sardine1,800 mgFish Oil in System-Six against 1,990 products1.8 g per serving; the middle half of products list 1 g to 2 g, the median 1.2 g.1.8 g

Higher than 70% of 1,990 products listing fish oil (median 1.2 g). Per day at the most servings: 3.6 g.

Eicosapentaenoic Acid18%324 mgEPA (Eicosapentaenoic Acid) in System-Six against 3,134 products324 mg per serving; the middle half of products list 120 mg to 590 mg, the median 300 mg.324 mg

Higher than 53% of 3,134 products listing EPA (eicosapentaenoic acid) (median 300 mg). Per day at the most servings: 648 mg.

Docosahexaenoic Acid12%216 mgDHA in System-Six against 3,627 products216 mg per serving; the middle half of products list 104 mg to 400 mg, the median 232 mg.216 mg

53% of 3,627 products listing DHA give more (median 232 mg). Per day at the most servings: 432 mg.

Garcinia fruit rind extract335 mgGarcinia in System-Six against 676 products335 mg per serving; the middle half of products list 200 mg to 1,000 mg, the median 500 mg.335 mg

67% of 676 products listing garcinia give more (median 500 mg). Per day at the most servings: 670 mg.

White Tea Leaf Extract300 mgWhite Tea in System-Six against 31 products300 mg per serving; the middle half of products list 20 mg to 150 mg, the median 90 mg.300 mg

Higher than 81% of 31 products listing white tea (median 90 mg). Per day at the most servings: 600 mg.

Epigallocatechin Gallate50%150 mgEGCG in System-Six against 291 products150 mg per serving; the middle half of products list 50 mg to 150 mg, the median 100 mg.150 mg

Higher than 71% of 291 products listing EGCG (median 100 mg). Per day at the most servings: 300 mg.

Green Tea Leaf Extract150 mgGreen Tea in System-Six against 2,595 products150 mg per serving; the middle half of products list 50 mg to 250 mg, the median 100 mg.150 mg

Higher than 58% of 2,595 products listing green tea (median 100 mg). Per day at the most servings: 300 mg.

Caffeine50%75 mgCaffeine in System-Six against 3,358 products75 mg per serving; the middle half of products list 100 mg to 275 mg, the median 200 mg.75 mg

86% of 3,358 products listing caffeine give more (median 200 mg). Per day at the most servings: 150 mg.

Schisandra Fruit Extractas Schisandra chinensis fruit extract4:1100 mgSchisandra in System-Six against 460 products100 mg per serving; the middle half of products list 50 mg to 240 mg, the median 108.75 mg.100 mg

50% of 460 products listing schisandra give more (median 108.75 mg). Per day at the most servings: 200 mg.

L-Carnitineas L-Carnitine Fumarate80 mgL-Carnitine in System-Six against 1,338 products80 mg per serving; the middle half of products list 110.5 mg to 1,000 mg, the median 500 mg.80 mg

80% of 1,338 products listing L-carnitine give more (median 500 mg). Per day at the most servings: 160 mg.

L-Theanine50 mgTheanine in System-Six against 1,602 products50 mg per serving; the middle half of products list 90 mg to 200 mg, the median 100 mg.50 mg

79% of 1,602 products listing theanine give more (median 100 mg). Per day at the most servings: 100 mg.

L-Tyrosine40 mgTyrosine in System-Six against 1,680 products40 mg per serving; the middle half of products list 150 mg to 989 mg, the median 500 mg.40 mg

92% of 1,680 products listing tyrosine give more (median 500 mg). Per day at the most servings: 80 mg.

Cayenne, Powder30,000 HU20 mgCapsicum in System-Six against 874 products20 mg per serving; the middle half of products list 25 mg to 100 mg, the median 44.5 mg.20 mg

76% of 874 products listing capsicum give more (median 44.5 mg). Per day at the most servings: 40 mg.

Ginger, Powder20 mgGinger in System-Six against 1,770 products20 mg per serving; the middle half of products list 25 mg to 150 mg, the median 60 mg.20 mg

77% of 1,770 products listing ginger give more (median 60 mg). Per day at the most servings: 40 mg.

Guarana (Paullinia cupana) powder20 mgGuarana in System-Six against 317 products20 mg per serving; the middle half of products list 50 mg to 300 mg, the median 125 mg.20 mg

88% of 317 products listing guarana give more (median 125 mg). Per day at the most servings: 40 mg.

Inositol20 mgInositol in System-Six against 4,042 products20 mg per serving; the middle half of products list 10 mg to 80 mg, the median 30 mg.20 mg

64% of 4,042 products listing inositol give more (median 30 mg). Per day at the most servings: 40 mg.

Mate (Yerba Mate) extract20 mgMate in System-Six against 131 products20 mg per serving; the middle half of products list 50 mg to 400 mg, the median 100 mg.20 mg

95% of 131 products listing mate give more (median 100 mg). Per day at the most servings: 40 mg.

Spirulina, Powder20 mgSpirulina in System-Six against 92 products20 mg per serving; the middle half of products list 187.5 mg to 1,000 mg, the median 500 mg.20 mg

91% of 92 products listing spirulina give more (median 500 mg). Per day at the most servings: 40 mg.

BioPerine Complex3 mg
BioPerineas Black Pepper Fruit Extract95% piperinein the blend, no amount given
Ginger Rhizome Extractas Gingerols5% gingerolsin the blend, no amount given

Source: NIH ODS Dietary Supplement Label Database, label 292134 (entered July 18, 2023), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • 96% of the 18,583 products that print an amount of vitamin C list more than its 8 mg of vitamin C (median 100 mg).
  • 91% of the 9,830 products that print an amount of thiamin list more than its 0.5 mg of thiamin (median 5 mg).
  • 91% of the 9,824 products that print an amount of riboflavin list more than its 0.5 mg of riboflavin (median 4 mg).
  • 79% of the 1,602 products that print an amount of theanine list more than its 50 mg of L-theanine (filed by NIH under theanine) (median 100 mg).
  • 92% of the 1,680 products that print an amount of tyrosine list more than its 40 mg of L-tyrosine (filed by NIH under tyrosine) (median 500 mg).
  • 88% of the 317 products that print an amount of guarana list more than its 20 mg of guarana (median 125 mg).

The NIH database records 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with System-Six's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: (Adult) As an addition to your reduced calorie diet and exercise plan, take three (3) Liquid Soft-Gels in the morning and three (3) Liquid Soft-Gels in the afternoon with meals and a full glass (8oz) of water. If caffeine keeps you up at night, do not take this product in the evening since it contains caffeine.
Warnings
Usage Warnings: Do not use if safety seal is broken. This product contains an ingredient that may affect blood sugar. This product contains niacin and may cause a temporary warming and tingling sensation.
Check with your doctor before using this product if you are using medication or have any medical conditions, including, but not limited to, heart disease, high blood pressure, an iron deficiency, a liver disorder or develop symptoms of liver trouble (such as abdominal pain, dark urine or jaundice).
It is recommended to limit additional caffeine intake while taking this product.
Do not use if you may become pregnant, are pregnant or nursing.
Do not exceed recommended daily intake.
Not intended for use by persons under 18. Keep out of reach of children.
Warning: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.
If caffeine keeps you up at night, do not take this product in the evening since it contains caffeine.
Contains: Fish (anchovy, sardine), Soy
Allergens and what it does not contain
No preservatives added.
Storage
Store in a cool, dry place.

Source: label statements in DSLD label 292134.

What else is on the label?

Other ingredients: Gelatin, Water, Purified, Glycerin, Beeswax, Sunflower Lecithin, Rice Flour, Annatto, Maltodextrin, Titanium Dioxide, Turmeric, Soybean Oil, St. John's Bread, Dicalcium Phosphate, Silicon Dioxide, Sodium Copper Chlorophyllin.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): Pass Quality Tested Guaranteed.

How many labels does System-Six have?

3 labels are on file under this name since June 25, 2015: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 292134 (current) Entered July 18, 2023 · on the market · 60 liquid softgels · UPC 7 10363 59875 4
  2. Label 57706 Entered March 24, 2016 · on the market · 100 liquid softgels · UPC 7 10363 26247 1
  3. Label 45030 Entered June 25, 2015 · off the market May 7, 2015 · 100 liquid softgels · UPC 7 10363 26247 1

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Irwin Naturals (manufacturer, distributor), Los Angeles, CA. All Irwin Naturals products.

Where next?