SeroSyn

by Metagenics · capsule · 90 vegetarian capsules

  • On the market (NIH)
  • UPC 7 55571 93421 5
  • DSLD label 295858
  • Serving 1 vegetarian capsule
  • 90 servings

SeroSyn by Metagenics lists 9 ingredients, 9 with an amount per serving of 1 vegetarian capsule, such as 10 mg of vitamin B6, 555 mcg DFE of metafolin, 250 mcg of vitamin B12 and 200 mg of chinese skullcap root extract. Its current label entered the NIH Dietary Supplement Label Database on September 25, 2023.

What is in SeroSyn?

Each row as the label prints it, per serving of 1 vegetarian capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

SeroSyn: Supplement Facts rows against the market (DSLD label 295858, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin B6as Pyridoxine Hydrochloride10 mg588%Vitamin B6 in SeroSyn against 15,277 products10 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg10 mg

Higher than 55% of 15,277 products listing vitamin B6 (median 6 mg). Per day at the most servings: 30 mg.

Metafolinas Folate555 mcg DFE139%
Vitamin B12as Methylcobalamin250 mcg10,417%Vitamin B12 in SeroSyn against 14,425 products250 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg250 mcg

Higher than 77% of 14,425 products listing vitamin B12 (median 36 mcg). Per day at the most servings: 750 mcg.

Chinese Skullcap Root Extract200 mgBaikal Skullcap in SeroSyn against 114 products200 mg per serving; the middle half of products list 40 mg to 200 mg, the median 90 mg.200 mg

Higher than 67% of 114 products listing baikal skullcap (median 90 mg). Per day at the most servings: 600 mg.

Flavones30%60 mg
L-5-Hydroxytryptophan100 mg5-HTP in SeroSyn against 676 products100 mg per serving; the middle half of products list 50 mg to 100 mg, the median 100 mg.100 mg

18% of 676 products listing 5-HTP give more (median 100 mg). Per day at the most servings: 300 mg.

Asian Ginseng Root Extract100 mgOriental Ginseng in SeroSyn against 706 products100 mg per serving; the middle half of products list 30 mg to 200 mg, the median 90 mg.100 mg

Higher than 51% of 706 products listing oriental ginseng (median 90 mg). Per day at the most servings: 300 mg.

Ginsenosides8%8 mgGinsenosides in SeroSyn against 54 products8 mg per serving; the middle half of products list 7 mg to 30 mg, the median 11 mg.8 mg

63% of 54 products listing ginsenosides give more (median 11 mg). Per day at the most servings: 24 mg.

L-Theanine80 mgTheanine in SeroSyn against 1,602 products80 mg per serving; the middle half of products list 90 mg to 200 mg, the median 100 mg.80 mg

75% of 1,602 products listing theanine give more (median 100 mg). Per day at the most servings: 240 mg.

Source: NIH ODS Dietary Supplement Label Database, label 295858 (entered September 25, 2023), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.

The NIH database records 3 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with SeroSyn's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: Take one capsule three times daily with food or as directed by your healthcare practitioner.
Warnings
Warning: Do not use if pregnant or nursing.
Caution: Not recommended for those under 18 years of age.
If taking antidepressant medication, particularly antidepressants such as MAO inhibitors or selective serotonin reuptake inhibitors (SSRIs), avoid use. If you have a medical condition - including symptomatic gastrointestinal disorders, or are taking medication - including over-the-counter cold medicine and high blood pressure medicines, consult your healthcare practitioner before use.
Use with caution when driving or operating machinery, may cause drowsiness.
Keep out of the reach of children.
Tamper evident: Do not use if safety seal is missing or broken.
Practitioner exclusive
Allergens and what it does not contain
This product is non-GMO, gluten-free, and vegetarian.
Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)
Storage
Storage: Keep tightly closed in a cool, dry place.

Source: label statements in DSLD label 295858.

What else is on the label?

Other ingredients: Hydroxypropylmethylcellulose, Microcrystalline Cellulose, Silica, Stearic Acid.

How many labels does SeroSyn have?

5 labels are on file under this name since December 22, 2019: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 295858 (current) Entered September 25, 2023 · on the market · 90 vegetarian capsules · UPC 7 55571 93421 5
  2. Label 267377 Entered May 19, 2022 · on the market · 90 capsules
  3. Label 216270 Entered March 24, 2020 · on the market · 30 capsules · UPC 7 55571 93420 8
  4. Label 216269 Entered March 24, 2020 · off the market September 7, 2022 · 90 capsules · UPC 7 55571 93421 5
  5. Label 209694 Entered December 22, 2019 · off the market December 27, 2019 · 30 capsules

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Metagenics (manufacturer), Gig Harbor, WA. All Metagenics products.

Where next?