SAM-e 400 mg
by SuperSmart · tablet or pill · 60 gastro-resistant capsules
- On the market (NIH)
- DSLD label 332492
- Serving 1 to 2 tablets; amounts per 2 tablets
- 30 servings
SAM-e 400 mg by SuperSmart lists 2 ingredients, 2 with an amount per serving of 2 tablets, such as 800 mg of S-adenosyl methionine. Its current label entered the NIH Dietary Supplement Label Database on June 25, 2025.
What is in SAM-e 400 mg?
Each row as the label prints it, per serving of 2 tablets. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).
| Ingredient | Amount | % DV | Among products listing it |
|---|---|---|---|
| S-Adenosyl Methionineelemental | 800 mg | Higher than 96% of 163 products listing SAMe (median 200 mg). | |
| S-Adenosyl L-Methionine-Disulfate P-Toluenesulfonate | 1,600 mg |
Source: NIH ODS Dietary Supplement Label Database, label 332492 (entered June 25, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.
Is that a lot?
The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:
- Its 800 mg of S-adenosyl methionine (filed by NIH under SAMe) is higher than 96% of the 163 SAMe products that print an amount; 5 list more.
The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.
The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.
Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.
Which products have the closest formulas?
6 products list the very same ingredients; the nearest amounts come first.
- SAM-e 1000 mgMental Refreshment same ingredients
- SAMe (S,S Isomer) 1100 mgNusaPure same ingredients
- SAM-e 500 mgNasaBe'Ahava same ingredients
- SAM-e 1500 mgMental Refreshment same ingredients
- SAM-e 1500 mgNasaBe'Ahava same ingredients
- SAM-e 400 mgGNC · off the market same ingredients
Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.
What does the label say about taking it?
Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.
- Directions
- Directions: Take one or two tablets a day, on an empty stomach.
- Warnings
- Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.
- Keep out of childrens' reach.
- As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem. Warning: Anyone taking prescription anti-depressants should consult their doctor before using this product. Those being treated for Parkinson's disease or manic depression (bi-polar depression) should not take SAM-e. This product is a nutritional supplement, it is not a medicine.
- Storage
- Store away from direct light, heat and humidity.
Source: label statements in DSLD label 332492.
What else is on the label?
Other ingredients: Microcrystalline Cellulose, Magnesium Hydroxide, Stearic Acid, Calcium Chloride Anhydrous, Magnesium Stearate, Colloidal Silica Anhydrous, Calcium Oxide, Talc, Shellac, Arginine, Glycerol, Silicon Dioxide, Sodium Alginate.
How many labels does SAM-e 400 mg have?
One label is on file, entered on June 25, 2025.
- Label 332492 (current) Entered June 25, 2025 · on the market · 60 gastro-resistant capsules
Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).
Who makes it?
The label names SN Worldwide Unipessoal, LDA (distributor), Funchal, Portugal. All SuperSmart products.