PureDefense w/NAC

by Pure Encapsulations · capsule · 120 capsules

  • On the market (NIH)
  • UPC 7 66298 01238 4
  • DSLD label 278301
  • Serving 2 capsules
  • 60 servings

PureDefense w/NAC by Pure Encapsulations lists 7 ingredients, 7 with an amount per serving of 2 capsules, such as 250 mg of vitamin C, 25 mcg (1,000 IU) of vitamin D, 7.5 mg of zinc and 450 mg of N-acetyl-L-cysteine. Its current label entered the NIH Dietary Supplement Label Database on December 13, 2022.

What is in PureDefense w/NAC?

Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

PureDefense w/NAC: Supplement Facts rows against the market (DSLD label 278301, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin Cas Ascorbic Acid250 mg278%Vitamin C in PureDefense w/NAC against 18,583 products250 mg per serving; the middle half of products list 60 mg to 270 mg, the median 100 mg.DV 90 mgUL 2,000 mg250 mg

Higher than 68% of 18,583 products listing vitamin C (median 100 mg). Per day at the most servings: 500 mg.

Vitamin Das Cholecalciferol, Vitamin D3Vitamin D (Form: as Cholecalciferol (Alt. Name: D3)) Note: 1,000 IU25 mcg (1,000 IU)125%Vitamin D in PureDefense w/NAC against 14,175 products25 mcg per serving; the middle half of products list 10 mcg to 25 mcg, the median 15 mcg.DV 20 mcgUL 100 mcg25 mcg

Higher than 59% of 14,175 products listing vitamin D (median 15 mcg). Per day at the most servings: 50 mcg.

Zincas Zinc CitrateZinc (Form: as Zinc Citrate)7.5 mg68%Zinc in PureDefense w/NAC against 13,186 products7.5 mg per serving; the middle half of products list 5 mg to 15 mg, the median 11 mg.DV 11 mgUL 40 mg7.5 mg

63% of 13,186 products listing zinc give more (median 11 mg). Per day at the most servings: 15 mg.

N-Acetyl-L-CysteineN-Acetyl-L-Cysteine Note: free-form450 mgN-Acetyl Cysteine in PureDefense w/NAC against 1,259 products450 mg per serving; the middle half of products list 55 mg to 500 mg, the median 150 mg.450 mg

Higher than 73% of 1,259 products listing N-acetyl cysteine (median 150 mg). Per day at the most servings: 900 mg.

EpiCoras Yeast Fermentate, DriedEpiCor dried Yeast Fermentate Complex (Form: from Saccharomyces cerevisiae Genus: Saccharomyces Species: cerevisiae)250 mgSaccharomyces cerevisiae in PureDefense w/NAC against 168 products250 mg per serving; the middle half of products list 211.25 mg to 500 mg, the median 500 mg.250 mg

62% of 168 products listing saccharomyces cerevisiae give more (median 500 mg). Per day at the most servings: 500 mg.

European Elder (Elderberry) (Sambucus nigra) extract200 mgEuropean Elder in PureDefense w/NAC against 920 products200 mg per serving; the middle half of products list 50 mg to 400 mg, the median 150 mg.200 mg

Higher than 54% of 920 products listing european elder (median 150 mg). Per day at the most servings: 400 mg.

Quercetin25 mgQuercetin in PureDefense w/NAC against 1,548 products25 mg per serving; the middle half of products list 26.5 mg to 250 mg, the median 100 mg.25 mg

75% of 1,548 products listing quercetin give more (median 100 mg). Per day at the most servings: 50 mg.

Source: NIH ODS Dietary Supplement Label Database, label 278301 (entered December 13, 2022), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.

The NIH database records 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with PureDefense w/NAC's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Recommendations: As a dietary supplement, take 2 capsules, twice daily, with meals.
Warnings
Warning: If you are pregnant or lactating, have any health condition or are taking any medications, particularly immunosuppressants, consult your health professional before use.
Keep out of the reach of children.
Use only if safety seal is intact.
Allergens and what it does not contain
Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org GFCO.org
Gluten-free, Non-GMO & Hypoallergenic
Storage
Store in a cool, dry place.

Source: label statements in DSLD label 278301.

What else is on the label?

Other ingredients: Vegetarian Capsule, Ascorbyl Palmitate.

How many labels does PureDefense w/NAC have?

5 labels are on file under this name since November 21, 2018: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 278301 (current) Entered December 13, 2022 · on the market · 120 capsules · UPC 7 66298 01238 4
  2. Label 218985 Entered April 23, 2020 · off the market October 26, 2018 · 120 capsules · UPC 7 66298 01238 4
  3. Label 218980 Entered April 23, 2020 · off the market October 26, 2018 · 20 capsules · UPC 7 66298 01722 8
  4. Label 183201 Entered November 21, 2018 · on the market · 20 capsules · UPC 7 66298 01722 8
  5. Label 183198 Entered November 21, 2018 · off the market March 22, 2022 · 120 capsules · UPC 7 66298 01238 4

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Pure Encapsulations (manufacturer), Sudbury, MA. All Pure Encapsulations products.

Where next?