Optimized Tryptophan Plus
by Life Extension · capsule · 90 vegetarian capsules
- On the market (NIH)
- UPC 7 37870 17219 2
- DSLD label 328618
- Serving 3 vegetarian capsules
- 30 servings
Optimized Tryptophan Plus by Life Extension lists 5 ingredients, 3 with an amount per serving of 3 vegetarian capsules, such as 66 mg NE of niacin, 1,000 mg of L-tryptophan and 250 mg of L-lysine; 2 sit inside a blend without their own amounts. Its current label entered the NIH Dietary Supplement Label Database on April 24, 2025.
What is in Optimized Tryptophan Plus?
Each row as the label prints it, per serving of 3 vegetarian capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).
| Ingredient | Amount | % DV | Among products listing it |
|---|---|---|---|
| Niacinas NiacinamideNiacin equivalents | 66 mg NE | 413% | Higher than 85% of 12,413 products listing niacin (median 20 mg). 1.9 times the adult UL a day. |
| L-Tryptophan | 1,000 mg | Higher than 92% of 605 products listing tryptophan (median 123 mg). | |
| L-Lysineas L-Lysine Hydrochloride | 250 mg | 63% of 1,250 products listing lysine give more (median 500 mg). | |
| Proprietary Tryptophan Plus Blend | 285 mg | ||
| Perluxanas Hops Cone Extractstandardized | in the blend, no amount given | ||
| Rosemary Leaf Extractstandardized | in the blend, no amount given |
Source: NIH ODS Dietary Supplement Label Database, label 328618 (entered April 24, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.
Is that a lot?
The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:
- At 1 serving a day, the most its directions give, the label lists 66 mg of niacin, 1.9 times the adult Tolerable Upper Intake Level.
- Its 1,000 mg of L-tryptophan (filed by NIH under tryptophan) is higher than 92% of the 605 tryptophan products that print an amount; 20 list more.
The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.
The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.
Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.
Which products have the closest formulas?
The products whose ingredient lists overlap most with Optimized Tryptophan Plus's, rare ingredients counting for more.
- Optimized TryptoPure PlusLife Extension 4 shared, 66% alike
Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.
What does the label say about taking it?
Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.
- Directions
- Directions: Take three (3) capsules all at once before bedtime, or one capsule on an empty stomach before each meal, or as recommended by a healthcare practitioner. Best if taken separately from protein or amino acids.
- Warnings
- Read the entire label and follow the directions carefully.
- Caution: Consult your healthcare provider before using this product if you are taking medication for mood concerns, such as MAOIs or SSRIs.
- Use caution before driving or operating heavy machinery.
- Warnings: Keep out of reach of children.
- Do not exceed recommended dose. Do not purchase if outer seal is damaged.
- Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
- To report a serious adverse event or obtain product information, contact 1-866-280-2852.
- Allergens and what it does not contain
- Gluten free Non GMO LE Certified
- Storage
- Store tightly closed in a cool, dry place.
Source: label statements in DSLD label 328618.
What else is on the label?
Other ingredients: Cellulose, Microcrystalline Cellulose, Maltodextrin, Starch, Carboxymethyl Cellulose, Stearate, Silica.
Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): Non GMO LE Certified.
How many labels does Optimized Tryptophan Plus have?
4 labels are on file under this name since July 25, 2016: other sizes, label designs and reformulations. The current one leads this page.
- Label 328618 (current) Entered April 24, 2025 · on the market · 90 vegetarian capsules · UPC 7 37870 17219 2
- Label 232279 Entered August 23, 2020 · off the market August 9, 2023 · 90 vegetarian capsules · UPC 7 37870 17219 2
- Label 62852 Entered July 25, 2016 · off the market July 14, 2020 · 90 vegetarian capsules · UPC 7 37870 17219 2
- Label 62824 Entered July 25, 2016 · off the market April 1, 2016 · 90 vegetarian capsules · UPC 7 37870 17219 2
Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).
Who makes it?
The label names Quality Supplements and Vitamins, Inc. (distributor), Ft. Lauderdale, FL. All Life Extension products.