NAD+ Defender
by Renue By Science · capsule · 60 veggie caps
- Off the market since November 2023 (NIH)
- UPC 6 56165 99646 9
- DSLD label 286894
- Serving 1 vegetarian capsule
- 60 servings
NAD+ Defender by Renue By Science lists 3 ingredients, 3 with an amount per serving of 1 vegetarian capsule, such as 110 mg of calcium alpha-ketoglutarate, 60 mg of berberine and 60 mg of hyaluronic acid. Its current label entered the NIH Dietary Supplement Label Database on June 22, 2023.
What is in NAD+ Defender?
Each row as the label prints it, per serving of 1 vegetarian capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).
| Ingredient | Amount | % DV | Among products listing it |
|---|---|---|---|
| NAD+ Defender Formula | 230 mg | ||
| Calcium Alpha-Ketoglutarate | 110 mg | 8%* | 51% of 17,831 products listing calcium give more (median 115 mg). |
| Berberine | 60 mg | 87% of 419 products listing berberine give more (median 400 mg). | |
| Hyaluronic Acid | 60 mg | Higher than 57% of 900 products listing hyaluronic acid (median 50 mg). |
* % Daily Value computed from the printed amount and the FDA Daily Value (21 CFR 101.9); the label prints none for that row.
Source: NIH ODS Dietary Supplement Label Database, label 286894 (entered June 22, 2023), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.
Is that a lot?
Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.
The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.
The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.
Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.
Which products have the closest formulas?
The products whose ingredient lists overlap most with NAD+ Defender's, rare ingredients counting for more.
- BerbercapThorne Research · off the market 1 shared, 46% alike
- Berberine-500Thorne Research · off the market 1 shared, 46% alike
- Berberine 1,000Only Natural · off the market 1 shared, 46% alike
- Advanced Berberine 1200Bio Nutrition 1 shared, 46% alike
- Berberine 500 mgDr. Whitaker · off the market 1 shared, 46% alike
- Berberine 500 mgPatient One MediNutritionals · off the market 1 shared, 46% alike
Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.
What does the label say about taking it?
Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.
- Directions
- Suggested use Take one (1) vegetarian capsule daily.
- Warnings
- Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using.
- Allergens and what it does not contain
- No artificial colors, flavors or preservatives. Non-GMO.
- Storage
- Store in a cool, dry place.
- Do not use if safety seal is broken or missing.
Source: label statements in DSLD label 286894.
What else is on the label?
Other ingredients: Cellulose, Sunflower Lecithin, Rice Flour, Microcrystalline Cellulose.
Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): GMP Good Manufacturing Practice Certified.
How many labels does NAD+ Defender have?
One label is on file, entered on June 22, 2023.
- Label 286894 (current) Entered June 22, 2023 · off the market November 14, 2023 · 60 veggie caps · UPC 6 56165 99646 9
Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).
Who makes it?
The label names Renue By Science (distributor), Ponte Vedra Beach, FL. All Renue By Science products.