PlainVitamins

L-Methyl-MC

by Virtus Pharmaceuticals · tablet or pill · 90 tablets

  • On the market (NIH)
  • UPC 3 76439 20790 8
  • DSLD label 22191
  • Serving 1 to 2 tablets; amounts per 1 tablet
  • 90 servings

L-Methyl-MC by Virtus Pharmaceuticals lists 4 ingredients, 4 with an amount per serving of 1 tablet, such as 6 mg of L-methylfolate calcium, 5 mg of riboflavin, 50 mg of pyridoxine and 1 mg of cyanocobalamin. Its current label entered the NIH Dietary Supplement Label Database on December 24, 2013.

What is in L-Methyl-MC?

Each row as the label prints it, per serving of 1 tablet. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

L-Methyl-MC: Supplement Facts rows against the market (DSLD label 22191, January 2026 release)
IngredientAmount% DVAmong products listing it
L-Methylfolate Calciumas 6(S)-5-MTHF-CaL-Methylfolate Calcium (Form: or 6(S)-5-MTHF-Ca) Note: contains less than 1% d-methylfolate6 mgFolate in L-Methyl-MC against 7,022 products6,000 mcg per serving; the middle half of products list 200 mcg to 400 mcg, the median 400 mcg.6,000 mcg

Higher than over 99% of 7,022 products listing folate (median 400 mcg).

Riboflavin5 mg385%*Riboflavin in L-Methyl-MC against 9,824 products5 mg per serving; the middle half of products list 1.7 mg to 25 mg, the median 4 mg.DV 1.3 mg5 mg

Higher than 51% of 9,824 products listing riboflavin (median 4 mg).

Pyridoxineas Pyridoxine HydrochloridePyridoxine (Form: as Pyridoxine HCl)50 mg2,941%*Vitamin B6 in L-Methyl-MC against 15,277 products50 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg50 mg

Higher than 87% of 15,277 products listing vitamin B6 (median 6 mg).

Cyanocobalamin1 mg41,667%*Vitamin B12 in L-Methyl-MC against 14,425 products1,000 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg1,000 mcg

Higher than 89% of 14,425 products listing vitamin B12 (median 36 mcg).

* % Daily Value computed from the printed amount and the FDA Daily Value (21 CFR 101.9); the label prints none for that row.

Source: NIH ODS Dietary Supplement Label Database, label 22191 (entered December 24, 2013), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • Its 6,000 mcg of L-methylfolate calcium (filed by NIH under folate) is higher than over 99% of the 7,022 folate products that print an amount; 68 list more.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

3 products list the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
INDICATIONS AND USAGE: L-Methyl-MC is indicated for the distinct nutritional requirements of patients in need of dietary supplementation as determined by a licensed medical practitioner. L-Methyl-MC should be administered under the supervision of a licensed medical practitioner.
DOSAGE AND ADMINISTRATION: Usual adult dose is one to two tablets daily or as prescribed by a licensed medical practitioner. L-Methyl-MC is not recommended for use in children under the age of twelve.
DOSAGE AND ADMINISTRATION: Usual adult dose is one to two tablets or as prescribed by a licensed medical practitioner.
Warnings
WARNINGS: Caution is recommended in patients with a history of bipolar illness.
DRUG INTERACTIONS: Drugs which may interact with folate include: - Antiepileptic drugs (AED): The AED class including, but not limited to, phenytoin, carbamazepine, primidone, valproic acid, fosphenytoin, valproate, phenobarbital and lamotrigine have been shown to impair folate absorption and increase the metabolism of circulating folate. - Additionally, concurrent use of folic acid has been associated with enhanced phenytoin metabolism, lowering the level of the AED in the blood and allowing breakthrough seizures to occur. Caution should be used when prescribing this product among patients who are receiving treatment with phenytoin and other anticonvulsants. - Capecitabine: Folinic acid (5-formyltetrahydrofolate) may increase the toxicity of Capecitabine. - Cholestyramine: Reduces folic acid absorption and reduces serum folate levels. - Colestipol: Reduces folic acid absorption and reduces serum folate levels. - Cycloserine: Reduces folic acid absorption and reduces serum folate levels. - Dihydrofolate Reductase Inhibitors (DHFRI): DHFRIs block the conversion of folic acid to its active forms, and lower plasma and red blood cell folate levels. DHFRIs include aminopterin, methotrexate, pyrimethamine, triamterene, and trimethoprim. - Fluoxetine: Fluoxetine exerts a noncompetitive inhibition of the 5-methyltetrahydrofolate active transport in the intestine. - Isotretinoin: Reduced folate levels have occurred in some patients taking isotretinoin. - L-dopa, triamterene, colchicine, and trimethoprim may decrease plasma folate levels. - Nonsteroidal Anti-inflammatory Drugs (NSAIDs): NSAIDs have been shown to inhibit some folate dependent enzymes in laboratory experiments. NSAIDs include ibuprofen, naproxen, indomethacin and sulindac. - Oral Contraceptives: Serum folate levels may be depressed by oral contraceptive therapy. - Methylprednisolone: Reduced serum folate levels have been noted after treatment with methylprednisolone. - Pancreatic Enzymes: Reduced serum folate levels have occurred in some patients taking pancreatic extracts, such a pancreatin and pancrelipase. - Pentamidine: Reduced folate levels have been seen with prolonged intravenous pentamidine. • Pyrimethamine: High levels of folic acid may result in decreased serum levels of pyrimethamine.
Call your medical practitioner about side effects.
KEEP THIS OUT OF THE REACH OF CHILDREN.
PRECAUTIONS: General: Folate, when administered as a single agent in doses about 0.1 mg daily, may obscure the detection of vitamin B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations). Folate therapy alone is inadequate for treatment of a vitamin B12 deficiency.
ADVERSE REACTIONS: Allergic sensitization has been reported following both oral and parental administration of folic acid, and may possibly occur with other forms of folate.
CONTRAINDICATIONS: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.
- Smoking and Alcohol: Reduced serum folate levels have been noted.
PREGNANCY and NURSING MOTHERS L-Methyl-MC is not intended for use as a prenatal/postnatal multivitamin for lactating and non-lactating mothers. This product contains B vitamins. Talk with your medical practitioner before using L-Methyl-MC if pregnant or lactating.
Paresthesia, somnolence, nausea, and headaches have been reported with vitamin B6. Mild transient diarrhea, polycythemia vera, itching, transitory exanthema and the feeling of swelling of the entire body have been associated with vitamin B12. If headaches occur with the use of this product, consult your medical practitioner.
- Sulfasalazine: Inhibits the absorption and metabolism of folic acid. - Metformin treatment in patients with type 2 diabetes decreases serum folate. - Warfarin can produce significant impairment in folate status after a 6-month therapy. - Folinic acid may enhance the toxicity of fluorouracil. - Concurrent administration of chloramphenicol and folinic acid in folate-deficient patients may result in antagonism of the haematopoietic response to folate. - Caution should be exercised with the concomitant use of folinic acid and trimethoprim-sulfamethoxazole for the acute treatment of Pneumocystis carinii pneumonia in patients with HIV infection as it is associated with increased rates of treatment failure and mortality in a placebo controlled study. Drugs which interact with vitamin B6: - Vitamin B6 should not be given to patients receiving the drug levodopa because the action of levodopa is antagonized by vitamin B6. However, vitamin B6 may be used concurrently in patients receiving a preparation containing both carbidopa and levodopa. Drugs which may interact with vitamin B12: • Antibiotics, cholestyramine, colchicines, colestipol, metformin, para-aminosalicylic, and potassium chloride may decrease the absorption of vitamin B12. • Nitrous oxide can produce a functional vitamin B12 deficiency.
L-Methyl-MC should be administered under the supervision of a licensed medical practitioner.
L-Methyl-MC is not recommended for use in children under the age of twelve.
If you are pregnant or nursing a baby, please ask a health professional.
KEEP THIS OUT OF REACH OF CHILDREN.
All prescriptions using this product shall be pursuant to state statues as applicable. This is not an Orange Book product.
Storage
STORAGE: Store at Controlled Room Temperature 15(0)-30(0)C (59(0)-86(0)F). [See USP]. Protect from light and moisture. Dispense in a tight, light-resistant container.
Store at controlled room temperature 15(0)-30(0)C (59(0)-86(0)F). [See USP]. Protect from light and moisture.

Source: label statements in DSLD label 22191.

What else is on the label?

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, FD&C Blue #1, Titanium Dioxide, Modified Cellulose, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Polyethylene Glycol, Food Glaze.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): V Virtus PHARMACEUTICALS.

How many labels does L-Methyl-MC have?

One label is on file, entered on December 24, 2013.

  1. Label 22191 (current) Entered December 24, 2013 · on the market · 90 tablets · UPC 3 76439 20790 8

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Virtus Pharmaceuticals, LLC (distributor), Tampa, FL. All Virtus Pharmaceuticals products.

Where next?