PlainVitamins

HisSynergy

by Metagenics · tablet or pill · 60 tablets

  • On the market (NIH)
  • UPC 7 55571 93841 1
  • DSLD label 295749
  • Serving 1 tablet
  • 60 servings

HisSynergy by Metagenics lists 6 ingredients, 6 with an amount per serving of 1 tablet, such as 250 mg of tribulus fruit extract, 200 mg of ashwagandha root extract and 50 mg of cowage seed extract. Its current label entered the NIH Dietary Supplement Label Database on August 23, 2023.

What is in HisSynergy?

Each row as the label prints it, per serving of 1 tablet. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

HisSynergy: Supplement Facts rows against the market (DSLD label 295749, January 2026 release)
IngredientAmount% DVAmong products listing it
Tribulus Fruit Extractas Tribulus terrestris Fruit Extract10:1 extract250 mgTribulus in HisSynergy against 555 products250 mg per serving; the middle half of products list 100 mg to 750 mg, the median 300 mg.250 mg

51% of 555 products listing tribulus give more (median 300 mg).

Saponinsstandardized to 40% saponins100 mgSaponins (unspecified) in HisSynergy against 42 products100 mg per serving; the middle half of products list 46.75 mg to 354.38 mg, the median 181.52 mg.100 mg

60% of 42 products listing saponins (unspecified) give more (median 181.52 mg).

Ashwagandha Root Extract15:1 extract200 mgAshwagandha in HisSynergy against 1,646 products200 mg per serving; the middle half of products list 125 mg to 500 mg, the median 250 mg.200 mg

51% of 1,646 products listing ashwagandha give more (median 250 mg).

Withanolidesstandardized to 1% withanolides2 mgWithanolide in HisSynergy against 79 products2 mg per serving; the middle half of products list 3.13 mg to 20 mg, the median 8 mg.2 mg

86% of 79 products listing withanolide give more (median 8 mg).

Cowage Seed Extract50 mgCowhage in HisSynergy against 417 products50 mg per serving; the middle half of products list 60 mg to 400 mg, the median 125 mg.50 mg

75% of 417 products listing cowhage give more (median 125 mg).

Levodopastandardized to 20% levodopa10 mgL-DOPA in HisSynergy against 38 products10 mg per serving; the middle half of products list 65 mg to 150 mg, the median 100 mg.10 mg

92% of 38 products listing L-DOPA give more (median 100 mg).

Source: NIH ODS Dietary Supplement Label Database, label 295749 (entered August 23, 2023), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • 92% of the 38 products that print an amount of L-DOPA list more than its 10 mg of levodopa (filed by NIH under L-DOPA) (median 100 mg).

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

1 product lists the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: Take as directed by your healthcare practitioner.
Warnings
Caution: If taking levodopa containing medications, consult your healthcare practitioner before use.
To be taken under supervision of a healthcare provider.
Keep out of the reach of children.
Practitioner Exclusive
Allergens and what it does not contain
This product is non-GMO, gluten-free, and vegetarian.
Certified gluten free GFCO.org (Gluten Free Certification Organization)

Source: label statements in DSLD label 295749.

What else is on the label?

Other ingredients: Microcrystalline Cellulose, Cellulose, Croscarmellose Sodium, Stearic Acid, Silica, Hypromellose, Medium Chain Triglyceride, Hydroxypropyl Cellulose.

How many labels does HisSynergy have?

4 labels are on file under this name since December 22, 2019: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 295749 (current) Entered August 23, 2023 · on the market · 60 tablets · UPC 7 55571 93841 1
  2. Label 267845 Entered June 16, 2022 · on the market · 60 tablets
  3. Label 216502 Entered March 24, 2020 · off the market September 7, 2022 · 60 tablets · UPC 7 55571 93841 1
  4. Label 209602 Entered December 22, 2019 · off the market December 20, 2019 · 60 tablets

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Metagenics (manufacturer), Gig Harbor, WA. All Metagenics products.

Where next?