PlainVitamins

Endothelial Defense Pomegranate Plus

by Life Extension · softgel capsule · 60 softgels

  • On the market (NIH)
  • UPC 7 37870 24976 4
  • DSLD label 328442
  • Serving 2 softgels
  • 30 servings

Endothelial Defense Pomegranate Plus by Life Extension lists 6 ingredients, 6 with an amount per serving of 2 softgels, such as 500 mg of cardiose flavonoid glycoside, 400 mg of pomella, 137.5 mg of proprietary pomegranate blend and 100 mg of pomegranate fruit extract, beside 3 Nutrition Facts rows (calories, fat and the like). Its current label entered the NIH Dietary Supplement Label Database on April 24, 2025.

What is in Endothelial Defense Pomegranate Plus?

Each row as the label prints it, per serving of 2 softgels. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Endothelial Defense Pomegranate Plus: Supplement Facts rows against the market (DSLD label 328442, January 2026 release)
IngredientAmount% DVAmong products listing it
Calories20 Calories
Total Fat1.5 g2%Fat (unspecified) in Endothelial Defense Pomegranate Plus against 11,965 products1.5 g per serving; the middle half of products list 1 g to 2.5 g, the median 1.5 g.1.5 g

44% of 11,965 products listing fat (unspecified) give more (median 1.5 g).

Total Carbohydrates1 g1%Carbohydrate in Endothelial Defense Pomegranate Plus against 21,979 products1 g per serving; the middle half of products list 1 g to 6 g, the median 3 g.1 g

74% of 21,979 products listing carbohydrate give more (median 3 g).

Proteinless than 1 g
Cardiose Flavonoid Glycosideas Immature Sweet Orange, Rutinoside500 mgFlavonoid in Endothelial Defense Pomegranate Plus against 2,343 products500 mg per serving; the middle half of products list 25 mg to 100 mg, the median 50 mg.500 mg

Higher than 94% of 2,343 products listing flavonoid (median 50 mg).

Pomellaas Pomegranate Fruit Extractstd. to 30% punicalagins400 mgPomegranate in Endothelial Defense Pomegranate Plus against 860 products637.5 mg per serving; the middle half of products list 12.5 mg to 250 mg, the median 70.5 mg.637.5 mg

Higher than 93% of 860 products listing pomegranate (median 70.5 mg).

Proprietary Pomegranate Blendas Pomegranate flower extract, Pomegranate seed Oil, Punicic Acid137.5 mg
Pomegranate Fruit Extract5:1 extract100 mg
Extramelas Melon Fruit Pulp Concentrate36 mgMelon in Endothelial Defense Pomegranate Plus against 34 products36 mg per serving; the middle half of products list 10 mg to 10 mg, the median 10 mg.36 mg

Higher than 88% of 34 products listing melon (median 10 mg).

Superoxide Dismutaseenzyme activity500 IU

Source: NIH ODS Dietary Supplement Label Database, label 328442 (entered April 24, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • Its 500 mg of cardiose flavonoid glycoside (filed by NIH under flavonoid) is higher than 94% of the 2,343 flavonoid products that print an amount; 65 list more.
  • Its 637.5 mg of pomella (filed by NIH under pomegranate) (3 rows of the label added together) is higher than 93% of the 860 pomegranate products that print an amount; 54 list more.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Endothelial Defense Pomegranate Plus's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: Take two (2) softgels daily before breakfast, or as recommended by a healthcare practitioner.
Warnings
Read the entire label and follow the directions carefully.
Warnings: Keep out of reach of children.
Do not exceed recommended dose. Do not purchase if outer seal is damaged.
Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
To report a serious adverse event or obtain product information, contact 1-866-280-2852.
Allergens and what it does not contain
Gluten Free Non GMO Le Certified
Storage
Store tightly closed in a cool, dry place.

Source: label statements in DSLD label 328442.

What else is on the label?

Other ingredients: Extra Virgin Olive Oil, Gelatin, Glycerin, Sunflower Lecithin, Water, Purified, Beeswax, Carob, Dextrin.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): Non GMO Le Certified.

How many labels does Endothelial Defense Pomegranate Plus have?

2 labels are on file under this name since August 23, 2020: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 328442 (current) Entered April 24, 2025 · on the market · 60 softgels · UPC 7 37870 24976 4
  2. Label 232748 Entered August 23, 2020 · on the market · 60 softgels · UPC 7 37870 24976 4

DSLD also links this label to: Endothelial Defense with Full-Spectrum Pomegranate (image difference, same product), Endothelial Defense (image difference, same product), Endothelial Defense (image difference, same product), Endothelial Defense With Pomegranate Complete And Cordiart (image difference, same product), Endothelial Defense With Pomegranate Complete And Cordiart (image difference, same product), Endothelial Defense With Full-Spectrum Pomegranate And Cordiart (image difference, same product), Endothelial Defense Pomegranate Complete (image difference, same product).

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Quality Supplements and Vitamins, Inc. (distributor), Ft. Lauderdale, FL. All Life Extension products.

Where next?