PlainVitamins

Double Potency 5-HTP Extra

by Irwin Naturals · softgel capsule · 60 liquid soft-gels

  • On the market (NIH)
  • UPC 7 10363 58537 2
  • DSLD label 323281
  • Serving 2 liquid soft-gels
  • 30 servings

Double Potency 5-HTP Extra by Irwin Naturals lists 12 ingredients, 12 with an amount per serving of 2 liquid soft-gels, such as 12.5 mcg (500 IU) of vitamin D, 10 mg of vitamin B6, 50 mg of magnesium and 800 mg of fish oil, beside 3 Nutrition Facts rows (calories, fat and the like). Its current label entered the NIH Dietary Supplement Label Database on January 23, 2025.

What is in Double Potency 5-HTP Extra?

Each row as the label prints it, per serving of 2 liquid soft-gels. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Double Potency 5-HTP Extra: Supplement Facts rows against the market (DSLD label 323281, January 2026 release)
IngredientAmount% DVAmong products listing it
Calories15 Calories
Total Fat1 g1%Fat (unspecified) in Double Potency 5-HTP Extra against 11,965 products1 g per serving; the middle half of products list 1 g to 2.5 g, the median 1.5 g.1 g

56% of 11,965 products listing fat (unspecified) give more (median 1.5 g). Per day at the most servings: 2 g.

Cholesterol10 mg3%Cholesterol in Double Potency 5-HTP Extra against 5,275 products10 mg per serving; the middle half of products list 5 mg to 45 mg, the median 15 mg.10 mg

56% of 5,275 products listing cholesterol give more (median 15 mg). Per day at the most servings: 20 mg.

Total Carbohydrates1 g1%Carbohydrate in Double Potency 5-HTP Extra against 21,979 products1 g per serving; the middle half of products list 1 g to 6 g, the median 3 g.1 g

74% of 21,979 products listing carbohydrate give more (median 3 g). Per day at the most servings: 2 g.

Vitamin Das Cholecalciferol500 IU12.5 mcg (500 IU)63%Vitamin D in Double Potency 5-HTP Extra against 14,175 products12.5 mcg per serving; the middle half of products list 10 mcg to 25 mcg, the median 15 mcg.DV 20 mcgUL 100 mcg12.5 mcg

53% of 14,175 products listing vitamin D give more (median 15 mcg). Per day at the most servings: 25 mcg.

Vitamin B6as Pyridoxine Hydrochloride10 mg588%Vitamin B6 in Double Potency 5-HTP Extra against 15,277 products10 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg10 mg

Higher than 55% of 15,277 products listing vitamin B6 (median 6 mg). Per day at the most servings: 20 mg.

Magnesiumas Magnesium Citrate50 mg12%Magnesium in Double Potency 5-HTP Extra against 14,003 products50 mg per serving; the middle half of products list 30 mg to 200 mg, the median 86 mg.UL 350 mgDV 420 mg50 mg

59% of 14,003 products listing magnesium give more (median 86 mg). Per day at the most servings: 100 mg.

Fish Oilas Anchovy, Sardine800 mgFish Oil in Double Potency 5-HTP Extra against 1,990 products0.8 g per serving; the middle half of products list 1 g to 2 g, the median 1.2 g.0.8 g

77% of 1,990 products listing fish oil give more (median 1.2 g). Per day at the most servings: 1.6 g.

Eicosapentaenoic Acid18%144 mgEPA (Eicosapentaenoic Acid) in Double Potency 5-HTP Extra against 3,134 products144 mg per serving; the middle half of products list 120 mg to 590 mg, the median 300 mg.144 mg

72% of 3,134 products listing EPA (eicosapentaenoic acid) give more (median 300 mg). Per day at the most servings: 288 mg.

Docosahexaenoic Acid12%96 mgDHA in Double Potency 5-HTP Extra against 3,627 products96 mg per serving; the middle half of products list 104 mg to 400 mg, the median 232 mg.96 mg

81% of 3,627 products listing DHA give more (median 232 mg). Per day at the most servings: 192 mg.

5-Hydroxytryptophanas Griffonia simplicifolia Seed Extract100 mg5-HTP in Double Potency 5-HTP Extra against 676 products100 mg per serving; the middle half of products list 50 mg to 100 mg, the median 100 mg.100 mg

18% of 676 products listing 5-HTP give more (median 100 mg). Per day at the most servings: 200 mg.

Lemon Balm Leaf Extract4:1100 mgLemon balm in Double Potency 5-HTP Extra against 475 products100 mg per serving; the middle half of products list 50 mg to 200 mg, the median 100 mg.100 mg

42% of 475 products listing lemon balm give more (median 100 mg). Per day at the most servings: 200 mg.

L-Theanine100 mgTheanine in Double Potency 5-HTP Extra against 1,602 products100 mg per serving; the middle half of products list 90 mg to 200 mg, the median 100 mg.100 mg

47% of 1,602 products listing theanine give more (median 100 mg). Per day at the most servings: 200 mg.

Damiana Leaf Extract4:175 mgDamiana in Double Potency 5-HTP Extra against 198 products75 mg per serving; the middle half of products list 50 mg to 450 mg, the median 100 mg.75 mg

60% of 198 products listing damiana give more (median 100 mg). Per day at the most servings: 150 mg.

Holy Basil Herb Extractas Ocimum sanctum Herb Extract75 mgHoly Basil in Double Potency 5-HTP Extra against 387 products75 mg per serving; the middle half of products list 50 mg to 400 mg, the median 129 mg.75 mg

67% of 387 products listing holy basil give more (median 129 mg). Per day at the most servings: 150 mg.

Saffron Flower, Stigma Extractas Crocus sativus Flower Extract, Crocus sativus Stigma Extract5 mgSaffron in Double Potency 5-HTP Extra against 201 products5 mg per serving; the middle half of products list 20 mg to 88.5 mg, the median 30 mg.5 mg

97% of 201 products listing saffron give more (median 30 mg). Per day at the most servings: 10 mg.

BioPerine Complexas BioPerine, Ginger Rhizome Extract95% piperine, 5% gingerols3 mg

Source: NIH ODS Dietary Supplement Label Database, label 323281 (entered January 23, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • 97% of the 201 products that print an amount of saffron list more than its 5 mg of saffron (median 30 mg).

The NIH database records 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Double Potency 5-HTP Extra's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: (Adult) Take two (2) liquid soft-gels twice daily with meals.
Warnings
Usage warnings: Do not use if safety seal is broken. Some people may experience drowsiness. Exercise caution if driving a vehicle or operating machinery. Do not exceed recommended daily intake. Warning: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.
Check with your doctor before using this product if you are using medication, including anti-depressants and pain medication, or have any medical conditions, including digestive disorders. Do not use if you may become pregnant, are pregnant or nursing.
Not intended for use by persons under 18. Keep out of reach of children.
Contains: Fish (anchovy, sardine), soy
Allergens and what it does not contain
No preservatives added.
Storage
Store in a cool, dry place.

Source: label statements in DSLD label 323281.

What else is on the label?

Other ingredients: Gelatin, Water, Purified, Glycerin, Beeswax, Soy Lecithin, Turmeric, Titanium Dioxide, Silicon Dioxide, Sodium Copper Chlorophyllin, Maltodextrin.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): Pass Quality Tested Guaranteed.

How many labels does Double Potency 5-HTP Extra have?

2 labels are on file under this name since November 19, 2021: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 323281 (current) Entered January 23, 2025 · on the market · 60 liquid soft-gels · UPC 7 10363 58537 2
  2. Label 256492 Entered November 19, 2021 · off the market June 1, 2023 · 60 liquid softgels · UPC 7 10363 58537 2

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Irwin Naturals (manufacturer, distributor), Los Angeles, CA. All Irwin Naturals products.

Where next?