PlainVitamins

Bio-Zyme

by Integrative Therapeutics · tablet or pill · 200 tablets

  • On the market (NIH)
  • UPC 8 71791 00087 2
  • DSLD label 305818
  • Serving 2 tablets
  • 100 servings

Bio-Zyme by Integrative Therapeutics lists 9 ingredients, 6 with an amount per serving of 2 tablets, such as 75 mg of trypsin, 50 mg of papain, 16 mg of bromelain and 10 mg of amylase; 3 sit inside a blend without their own amounts. Its current label entered the NIH Dietary Supplement Label Database on March 22, 2024.

What is in Bio-Zyme?

Each row as the label prints it, per serving of 2 tablets. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Bio-Zyme: Supplement Facts rows against the market (DSLD label 305818, January 2026 release)
IngredientAmount% DVAmong products listing it
Pancreatic Enzymes361 mg
AmylaseUSP units of activity: 81,250 USPin the blend, no amount given
ProteaseUSP units of activity: 81,250 USPin the blend, no amount given
LipaseUSP units of activity: 6,500in the blend, no amount given
Trypsin75 mgTrypsin in Bio-Zyme against 77 products75 mg per serving; the middle half of products list 35 mg to 100 mg, the median 75 mg.75 mg

30% of 77 products listing trypsin give more (median 75 mg). Per day at the most servings: 225 mg.

Papain50 mgPapain in Bio-Zyme against 607 products50 mg per serving; the middle half of products list 20 mg to 75 mg, the median 40 mg.50 mg

Higher than 55% of 607 products listing papain (median 40 mg). Per day at the most servings: 150 mg.

Bromelain16 mgBromelain in Bio-Zyme against 1,337 products16 mg per serving; the middle half of products list 25 mg to 200 mg, the median 50 mg.16 mg

83% of 1,337 products listing bromelain give more (median 50 mg). Per day at the most servings: 48 mg.

Amylase10 mgAmylase in Bio-Zyme against 326 products10 mg per serving; the middle half of products list 5 mg to 50 mg, the median 14 mg.10 mg

51% of 326 products listing amylase give more (median 14 mg). Per day at the most servings: 30 mg.

Lipase10 mgLipase in Bio-Zyme against 366 products10 mg per serving; the middle half of products list 5 mg to 25 mg, the median 10 mg.10 mg

45% of 366 products listing lipase give more (median 10 mg). Per day at the most servings: 30 mg.

Chymotrypsin2 mgChymotrypsin in Bio-Zyme against 49 products2 mg per serving; the middle half of products list 2 mg to 5 mg, the median 3 mg.2 mg

63% of 49 products listing chymotrypsin give more (median 3 mg). Per day at the most servings: 6 mg.

Source: NIH ODS Dietary Supplement Label Database, label 305818 (entered March 22, 2024), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient; 3 ingredients sit inside a blend, so their amounts cannot be compared.

The NIH database records 2 to 3 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

6 products list the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Recommendation: To relieve occasional muscle soreness and discomfort due to overexertion and exercise, adults take 2 tablets three times a day between meals. To support optimal digestion, take 2 tablets up to three times a day, before each meal.
Warnings
Not formulated for children.
Caution: If you are pregnant, nursing, have diabetes or if you are taking any medications, consult a healthcare professional before use.
Keep out of reach of children.
Safety sealed with inner seal. Do not use if seal is broken or missing.
Contains milk and sulfites.
Allergens and what it does not contain
Contains no artificial colors.
Storage
Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Source: label statements in DSLD label 305818.

What else is on the label?

Other ingredients: Cellulose, Potassium Bicarbonate, Lactose Monohydrate, Stearic Acid, Hypromellose, Sodium Croscarmellose, Magnesium Stearate, Glycerin, Silica.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): Quality Global Sourcing Bottled & Tested In The USA.

How many labels does Bio-Zyme have?

9 labels are on file under this name since July 25, 2013: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 305818 (current) Entered March 22, 2024 · on the market · 200 tablets · UPC 8 71791 00087 2
  2. Label 302486 Entered February 22, 2024 · off the market January 31, 2023 · 200 tablets · UPC 8 71791 00087 2
  3. Label 265883 Entered June 16, 2022 · off the market January 31, 2023 · 200 tablets · UPC 8 71791 00087 2
  4. Label 184917 Entered April 25, 2019 · off the market October 12, 2021 · 200 tablets · UPC 8 71791 00087 2
  5. Label 184920 Entered February 25, 2019 · on the market · 100 tablets · UPC 8 71791 00086 5
  6. Label 76961 Entered September 21, 2017 · off the market June 21, 2018 · 100 tablets · UPC 8 71791 00086 5
  7. Label 76960 Entered September 21, 2017 · off the market June 21, 2018 · 200 tablets · UPC 8 71791 00087 2
  8. Label 23552 Entered July 25, 2013 · off the market June 21, 2017 · 200 tablets · UPC 8 71791 00087 2
  9. Label 23535 Entered July 25, 2013 · off the market June 21, 2017 · 100 tablets · UPC 8 71791 00086 5

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Integrative Therapeutics, LLC (manufacturer), Green Bay, WI. All Integrative Therapeutics products.

Where next?