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Biotivia · Botanical with Nutrients supplement

Bio Span+ Bio-Enhanced 500 mg

7 ingredients on file in the NIH Dietary Supplement Label Database. Off-market, label data preserved for reference.

7
Ingredients
3
Nutrient categories
Top 58%
By ingredient count

Bio Span+ Bio-Enhanced 500 mg is a botanical with nutrients supplement by Biotivia in capsule form, listing 7 ingredients in the NIH Dietary Supplement Label Database (DSLD), maintained by the Office of Dietary Supplements at the National Institutes of Health. Currently listed as off-market (no longer available for purchase, but label data is preserved). Daily Value percentages shown below are based on FDA reference daily intake amounts for adults.

Product Details

Form
Capsule
Database Entry Date
2014-05-23
Ingredients
7

Supplement Facts (7 Ingredients)

Ingredient Group Amount % DV
Resveratrol 75% Polygonum Cuspidatum Extract Hu Zhang Not disclosed on label No DV
Yields 122.50 mg Trans-resveratrol Resveratrol Not disclosed on label No DV
Curcumin Curcumin Not disclosed on label No DV
Silymarin Silymarin Not disclosed on label No DV
Astragalus Astragalus Not disclosed on label No DV
Astragalus Astragalus Not disclosed on label No DV
Hydroxypropyl methyl cellulose Hypromellose Not disclosed on label No DV

How does Bio Span+ Bio-Enhanced 500 mg compare?

Ingredients listed on each label, against the botanical with nutrients category average of 16. Data from the NIH DSLD.

Bio Span+ Bio-Enhanced 500 mg7
1 Liver & Organ Quick Detox24
Botanical with Nutrients average16

Bio Span+ Bio-Enhanced 500 mg lists 17 ingredients fewer than 1 Liver & Organ Quick Detox. That is 9 below the botanical with nutrients average.

What the Label Data Shows

Bio Span+ Bio-Enhanced 500 mg is cataloged in the NIH Dietary Supplement Label Database (DSLD) as a botanical with nutrients supplement built from 7 ingredients from Biotivia, sold in capsule form. These ingredients span 3 nutrient categories, botanical, non-nutrient/non-botanical, other, reflecting a multi-component formula rather than a single-nutrient product.

Across a broader 7-ingredient formula, 7 of 7 carry no FDA reference-intake value, typical for a formula this size: larger blends tend to pull in botanicals, amino acids, and specialty compounds without an assigned Daily Value. Breadth like this isn't a red flag by itself.

A product's market status is worth checking before relying on this label. This product is currently listed as off-market in the DSLD, with its label first entered into the database on 2014-05-23. Once a product goes off-market, it is no longer manufactured or sold under this label, yet the DSLD keeps the record intact for historical reference, useful for researchers, anyone with an older bottle on hand, or tracking how formulations changed over time.

About the DSLD database

The DSLD is a label database, not an FDA approval list, under the 1994 DSHEA framework, dietary supplements do not require pre-market approval, and label information reflects what manufacturers self-declare rather than independent laboratory verification. This page presents factual label data for reference only and is not medical advice; consult a licensed healthcare provider before making decisions about any supplement.

Source: NIH Office of Dietary Supplements, Dietary Supplement Label Database (DSLD) Supplement label data for Bio Span+ Bio-Enhanced 500 mg: ingredients, % Daily Value, market status, brand · 2026 DSLD captures manufacturer-self-declared label information; the NIH does not verify accuracy or evaluate safety/efficacy. Dietary supplements are regulated under DSHEA 1994, no pre-market FDA approval is required.

Ingredient Breakdown by Category

botanical
3
Resveratrol 75% Polygonum Cuspidatum Extract, Astragalus, Astragalus
non-nutrient/non-botanical
3
Yields 122.50 mg Trans-resveratrol, Curcumin, Silymarin
other
1
Hydroxypropyl methyl cellulose

Daily Value Coverage

0
Above 100% DV
0
Below 100% DV
7
No DV Established

Frequently Asked Questions

What ingredients are in Bio Span+ Bio-Enhanced 500 mg?
Bio Span+ Bio-Enhanced 500 mg contains 7 ingredients. Ingredients span 3 categories: botanical, non-nutrient/non-botanical, other.
Who manufactures Bio Span+ Bio-Enhanced 500 mg?
Bio Span+ Bio-Enhanced 500 mg is was manufactured by Biotivia. It is classified as a Botanical with Nutrients supplement in capsule form.
Is Bio Span+ Bio-Enhanced 500 mg still available for purchase?
According to the NIH DSLD database, Bio Span+ Bio-Enhanced 500 mg is listed as off-market and may no longer be available for purchase.
What is the serving size of Bio Span+ Bio-Enhanced 500 mg?
The serving size is not specified.
What type of supplement is Bio Span+ Bio-Enhanced 500 mg?
Bio Span+ Bio-Enhanced 500 mg is classified as a "Botanical with Nutrients" supplement in the NIH database. This category includes products primarily composed of botanical with nutrients ingredients. DSLD sorts every supplement into one of 9 categories overall: Vitamin, Mineral, Botanical, Amino Acid & Protein, Non-Nutrient, Fat & Fatty Acid, Multi-Vitamin & Mineral, Botanical with Nutrients, or Other Combinations.
Data Sources & Methodology

Data as of 2025. Source: NIH Office of Dietary Supplements, Dietary Supplement Label Database (DSLD).

Supplement label data sourced from the Source: NIH Dietary Supplement Label Database (DSLD), maintained by the Office of Dietary Supplements at the National Institutes of Health. The DSLD contains label information from dietary supplement products marketed in the United States.

Daily Value (DV) percentages are based on Source: FDA 21 CFR 101.9 Reference Daily Intake (RDI) values for adults. Products marked "Off Market" may no longer be available for purchase but their label data remains in the database for reference.

Disclaimer, Not Medical Advice

Label data from the Source: NIH Dietary Supplement Label Database (DSLD). This information is for educational and reference purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting, stopping, or combining any dietary supplement, especially if you are pregnant, nursing, take prescription medication, or have a medical condition.

Every figure on PlainVitamins is rendered directly from the NIH Dietary Supplement Label Database (DSLD), no number is typed in by an editor. This page draws directly on the NIH DSLD, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.