Bio Span+ Bio-Enhanced 500 mg

by Biotivia · capsule · 60 vegetarian capsules

  • Off the market since March 2016 (NIH)
  • UPC 0 94922 17255 6
  • DSLD label 33047
  • Serving 2 capsules
  • 30 servings

Bio Span+ Bio-Enhanced 500 mg by Biotivia lists 6 ingredients, 6 with an amount per serving of 2 capsules, such as 150 mg of resveratrol 75% polygonum cuspidatum extract, 300 mg of curcumin, 200 mg of silymarin and 150 mg of astragalus. Its current label entered the NIH Dietary Supplement Label Database on May 23, 2014.

What is in Bio Span+ Bio-Enhanced 500 mg?

Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Bio Span+ Bio-Enhanced 500 mg: Supplement Facts rows against the market (DSLD label 33047, January 2026 release)
IngredientAmount% DVAmong products listing it
Resveratrol 75% Polygonum Cuspidatum Extract150 mgHu Zhang in Bio Span+ Bio-Enhanced 500 mg against 269 products150 mg per serving; the middle half of products list 50 mg to 400 mg, the median 150 mg.150 mg

47% of 269 products listing hu zhang give more (median 150 mg).

Yields 122.50 mg Trans-resveratrol122 mgResveratrol in Bio Span+ Bio-Enhanced 500 mg against 1,123 products122 mg per serving; the middle half of products list 20 mg to 125 mg, the median 50 mg.122 mg

Higher than 73% of 1,123 products listing resveratrol (median 50 mg).

CurcuminCurcumin Note: 95% standardized extract300 mgCurcumin in Bio Span+ Bio-Enhanced 500 mg against 550 products300 mg per serving; the middle half of products list 50 mg to 400 mg, the median 200 mg.300 mg

Higher than 67% of 550 products listing curcumin (median 200 mg).

Silymarin200 mgSilymarin in Bio Span+ Bio-Enhanced 500 mg against 208 products200 mg per serving; the middle half of products list 63.75 mg to 203 mg, the median 116 mg.200 mg

Higher than 67% of 208 products listing silymarin (median 116 mg).

Astragalusas PolysaccharidesAstragalus (Form: 20% Polysaccharides) Genus: Astragalus150 mgAstragalus in Bio Span+ Bio-Enhanced 500 mg against 604 products300 mg per serving; the middle half of products list 50 mg to 405 mg, the median 132.5 mg.300 mg

Higher than 72% of 604 products listing astragalus (median 132.5 mg).

Astragalusas Astragaloside IV150 mg

Source: NIH ODS Dietary Supplement Label Database, label 33047 (entered May 23, 2014), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Bio Span+ Bio-Enhanced 500 mg's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Usage Instructions: For 12 years of age or older take one capsules at least 1/2 hour before meal.
Warnings
Not to be used by children under the age of 12 or by pregnant or lactating women without the recommendation of one's physician.
Allergens and what it does not contain
No additives, fillers or glidants.
Storage
Storage Instructions: Keep in cool dark place or refrigerate. Replace cap tightly after use.

Source: label statements in DSLD label 33047.

What else is on the label?

Other ingredients: Hydroxypropyl methyl cellulose.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): CERTIFIED VEGAN AVA American Vegetarian Association; vcaps(R). Listed with: Certified Vegan (Vegan Action) (a seal is the label's claim; the certifier's own list confirms it).

How many labels does Bio Span+ Bio-Enhanced 500 mg have?

3 labels are on file under this name since October 25, 2013: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 33047 (current) Entered May 23, 2014 · off the market March 28, 2016 · 60 vegetarian capsules · UPC 0 94922 17255 6
  2. Label 18869 Entered November 25, 2013 · off the market February 28, 2013 · 60 vegetarian capsules · UPC 0 94922 17255 6
  3. Label 21491 Entered October 25, 2013 · off the market April 29, 2014 · 60 vegetarian capsules · UPC 0 94922 17255 6

DSLD also links this label to: Bio Span (image difference, same product).

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Biotivia LLC (manufacturer), Arlington, VA. All Biotivia products.

Where next?