Berberine Plus

by True Botanica · capsule · 120 capsules

On the market (NIH)
DSLD label 336204
Serving 2 capsules
60 servings

Berberine Plus by True Botanica lists 4 ingredients, 4 with an amount per serving of 2 capsules, such as 500 mg of berberine hydrochloride, 20 mg of barberry bark, root extract and 2 mg of bioperine Nature's thermonutrient. Its current label entered the NIH Dietary Supplement Label Database on August 22, 2025.

What is in Berberine Plus?

Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Berberine Plus: Supplement Facts rows against the market (DSLD label 336204, January 2026 release)
Ingredient	Amount	Among products listing it
Berberine Hydrochloride	500 mg	Higher than 55% of 419 products listing berberine (median 400 mg). Per day at the most servings: 1,000 mg.
Barberry Pentasas Barberry Root Ash Pentas, Barberry Root Pentas	40 mg
Barberry Bark, Root Extractas Berberis vulgaris Bark Extract, Berberis vulgaris Root Extract4:1 extract	20 mg	94% of 138 products listing barberry give more (median 75 mg). Per day at the most servings: 40 mg.
Bioperine Nature's Thermonutrientas Piper nigrum	2 mg	93% of 2,363 products listing black pepper give more (median 5 mg). Per day at the most servings: 4 mg.
Piperine95%	1.9 mg	93% of 203 products listing piperine give more (median 5 mg). Per day at the most servings: 3.8 mg.

Source: NIH ODS Dietary Supplement Label Database, label 336204 (entered August 22, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

94% of the 138 products that print an amount of barberry list more than its 20 mg of barberry (median 75 mg).
93% of the 2,363 products that print an amount of black pepper list more than its 2 mg of bioperine Nature's thermonutrient (filed by NIH under black pepper) (median 5 mg).
93% of the 203 products that print an amount of piperine list more than its 1.9 mg of piperine (median 5 mg).

The NIH database records 1 to 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Berberine Plus's, rare ingredients counting for more.

Berberine 1000 mgSuperSmart 2 shared, 54% alike
Piperine Extract Powder (95% Piperine)Z Natural Foods 2 shared, 46% alike
Berberine +BioPerineApproved Science 2 shared, 43% alike
BerberineFINAFLEX 2 shared, 43% alike
CoQ10 100 mgSports Research 2 shared, 39% alike
Curcumin & BerberineSwanson Superior Herbs · off the market 2 shared, 37% alike

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions: Suggested usage: Two capsules once or twice daily, or as suggested by your health care provider.
Warnings: Consult your health care provider before using this product if you are pregnant, lactating or have other medical concerns or compatibility issues.; Do not use this product if allergies to the listed ingredients are known to exist or if any adverse effects result after taking the first dose.; This product contains a desiccant package, which should not be eaten.; Keep out of the reach of children.
Allergens and what it does not contain: Contains no milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame, or soybeans. Gluten free.
Storage: Keep desiccant in the bottle until all capsules have been taken.

Source: label statements in DSLD label 336204.

What else is on the label?

Other ingredients: Microcrystalline Cellulose, Cellulose, Magnesium Stearate.

How many labels does Berberine Plus have?

One label is on file, entered on August 22, 2025.

Label 336204 (current) Entered August 22, 2025 · on the market · 120 capsules

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names True Botanica, LLC (distributor), Hartland, WI. All True Botanica products.