PlainVitamins

Acti-Zyme

by Natures Plus · capsule · 90 vegetarian capsules

  • Off the market since February 2022 (NIH)
  • UPC 0 97467 04454 8
  • DSLD label 199922
  • Serving 2 capsules
  • 45 servings

Acti-Zyme by Natures Plus lists 18 ingredients, 11 with an amount per serving of 2 capsules, such as 100 mg of fos, 83 mg of amylase, 67 mg of protease and 50 mg of lactospore; 7 sit inside a blend without their own amounts. Its current label entered the NIH Dietary Supplement Label Database on February 25, 2019.

What is in Acti-Zyme?

Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Acti-Zyme: Supplement Facts rows against the market (DSLD label 199922, January 2026 release)
IngredientAmount% DVAmong products listing it
Aminogen Proteolytic Enzyme Complex100 mg
Aspergillus nigerin the blend, no amount given
Aspergillus oryzaein the blend, no amount given
Legumase Oligosaccharide Enzyme Complex100 mg
Trichoderma reeseiin the blend, no amount given
Aspergillus oryzaein the blend, no amount given
Rhizopus oryzaein the blend, no amount given
Saccharomyces cerevisiaein the blend, no amount given
Aspergillus nigerin the blend, no amount given
Fosas ChicoryFOS (Form: from Chicory PlantPart: root Genus: Cichorium Species: intybus) (Alt. Name: Fructooligosaccharides) Note: lactic flora growth accelerant100 mgFructo-Oligosaccharides in Acti-Zyme against 526 products100 mg per serving; the middle half of products list 75 mg to 500 mg, the median 185 mg.100 mg

59% of 526 products listing fructo-oligosaccharides give more (median 185 mg).

AmylaseAmylase Note: 1500 RAU83 mgAmylase in Acti-Zyme against 326 products83 mg per serving; the middle half of products list 5 mg to 50 mg, the median 14 mg.83 mg

Higher than 87% of 326 products listing amylase (median 14 mg).

ProteaseProtease Note: 5,000 HUT67 mgProteolytic Enzymes (Proteases) in Acti-Zyme against 327 products67 mg per serving; the middle half of products list 10 mg to 100 mg, the median 30 mg.67 mg

Higher than 69% of 327 products listing proteolytic enzymes (proteases) (median 30 mg).

Lactosporeas L. sporogenesLactospore (Form: microencapsulated pure culture of L. sporogenes (Form: B. coagulans Genus: B. Species: coagulans) Genus: L. Species: sporogenes) Note: provides 300 million viable cells at the time of manufacture50 mgBacillus Coagulans in Acti-Zyme against 237 products50 mg per serving; the middle half of products list 10 mg to 66 mg, the median 20 mg.50 mg

Higher than 68% of 237 products listing bacillus coagulans (median 20 mg).

LactaseLactase Note: 50 ALU50 mgLactase in Acti-Zyme against 138 products50 mg per serving; the middle half of products list 10 mg to 197.5 mg, the median 34 mg.50 mg

Higher than 53% of 138 products listing lactase (median 34 mg).

LipaseLipase Note: 500 FIP50 mgLipase in Acti-Zyme against 366 products50 mg per serving; the middle half of products list 5 mg to 25 mg, the median 10 mg.50 mg

Higher than 83% of 366 products listing lipase (median 10 mg).

CellulaseCellulase Note: 500 CU50 mgCellulase in Acti-Zyme against 184 products50 mg per serving; the middle half of products list 3.74 mg to 30 mg, the median 10 mg.50 mg

Higher than 86% of 184 products listing cellulase (median 10 mg).

OxidaseOxidase Note: 5 GOTu50 mg
BromelainBromelain Note: 100 gelatin digesting units50 mgBromelain in Acti-Zyme against 1,337 products50 mg per serving; the middle half of products list 25 mg to 200 mg, the median 50 mg.50 mg

50% of 1,337 products listing bromelain give more (median 50 mg).

MaltaseMaltase Note: 32 DP5 mg
Bioperineas 1-PiperoylpiperidineBioperine (Form: standardized 95% 1-Piperoylpiperidine Note: 4.75 mg) PlantPart: fruit Genus: Piper Species: nigrum5 mgBlack Pepper in Acti-Zyme against 2,363 products5 mg per serving; the middle half of products list 5 mg to 10 mg, the median 5 mg.5 mg

33% of 2,363 products listing black pepper give more (median 5 mg).

Source: NIH ODS Dietary Supplement Label Database, label 199922 (entered February 25, 2019), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient; 7 ingredients sit inside a blend, so their amounts cannot be compared.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Acti-Zyme's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: Take two capsules immediately before or after a meal.
Warnings
Warnings: Keep tightly closed in a cool, dry place and out of reach of children.
Allergens and what it does not contain
Free from artificial colors and preservatives. Free from the common allergens wheat, soy and milk.
Gluten free

Source: label statements in DSLD label 199922.

What else is on the label?

Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Di-Calcium Phosphate, Stearic Acid, Silica, purified Water.

How many labels does Acti-Zyme have?

4 labels are on file under this name since October 25, 2012: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 199922 (current) Entered February 25, 2019 · off the market February 28, 2022 · 90 vegetarian capsules · UPC 0 97467 04454 8
  2. Label 68744 Entered December 23, 2016 · off the market June 11, 2018 · 90 vegetarian capsules · UPC 0 97467 04454 8
  3. Label 49452 Entered August 25, 2015 · off the market November 30, 2016 · 90 vegetable capsules · UPC 0 97467 04454 8
  4. Label 14159 Entered October 25, 2012 · off the market July 31, 2015 · 90 vegetarian capsules · UPC 0 97467 04454 8

DSLD also links this label to: Acti-Zyme (package size difference, same product).

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Natural Organics Laboratories, Inc. makers of Nature's Plus (manufacturer), Amityville, New York. All Natures Plus products.

Where next?