SAM-e 400 mg Double Strength
by PhysioLogics · tablet or pill · 30 enteric coated tablets
- Off the market since December 2013 (NIH)
- UPC 7 16963 50260 3
- DSLD label 3858
- Serving 1 tablet
SAM-e 400 mg Double Strength by PhysioLogics lists 3 ingredients, 3 with an amount per serving of 1 tablet, such as 1.17 mg of vitamin C, 0.82 mg of riboflavin and 400 mg of S-adenosylmethionine. Its current label entered the NIH Dietary Supplement Label Database on December 23, 2011.
What is in SAM-e 400 mg Double Strength?
Each row as the label prints it, per serving of 1 tablet. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).
| Ingredient | Amount | % DV | Among products listing it |
|---|---|---|---|
| Vitamin Cas Ascorbic Acid | 1.17 mg | 2% | 99% of 18,583 products listing vitamin C give more (median 100 mg). Per day at the most servings: 3.51 mg. |
| Riboflavin | 0.82 mg | 48% | 88% of 9,824 products listing riboflavin give more (median 4 mg). Per day at the most servings: 2.46 mg. |
| S-Adenosylmethionine | 400 mg | Higher than 53% of 163 products listing SAMe (median 200 mg). Per day at the most servings: 1,200 mg. |
Source: NIH ODS Dietary Supplement Label Database, label 3858 (entered December 23, 2011), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.
Is that a lot?
The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:
- 99% of the 18,583 products that print an amount of vitamin C list more than its 1.17 mg of vitamin C (median 100 mg).
The NIH database records 1 to 3 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.
The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.
Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.
Which products have the closest formulas?
The products whose ingredient lists overlap most with SAM-e 400 mg Double Strength's, rare ingredients counting for more.
- SAM-e 200 mgGNC · off the market 1 shared, 61% alike
- SAM-e 400 mgGNC · off the market 1 shared, 61% alike
- SAMe 200 mgBronson Laboratories 1 shared, 61% alike
- SAM-e 200 mgVitabase 1 shared, 61% alike
- SAMe Iso Active 200 mgNatural Factors · off the market 1 shared, 61% alike
- Ultra SAMePhysician's Preference · off the market 1 shared, 61% alike
Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.
What does the label say about taking it?
Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.
- Directions
- Directions: For adults, we recommend taking one (1) tablet one to three times daily, preferably on an empty stomach. In order to obtain maximum benefits, SAM-e should be taken at least 30 minutes prior to a meal or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.
- Warnings
- KEEP OUT OF REACH OF CHILDREN.
- WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use.
- Discontinue use and consult your doctor if any adverse reactions occur.
- For Health Care Professional Use Only
- TAMPER RESISTANT: Do not use if blister seal is cut, torn or open.
- Allergens and what it does not contain
- FREE OF: artificial flavor, preservatives, sugar, starch, milk, lactose, soy, gluten, wheat, yeast, fish, sodium.
- Storage
- Store in a dry place and avoid excessive heat.
Source: label statements in DSLD label 3858.
What else is on the label?
Other ingredients: Cellulose, Polymethacrylate, Citric Acid, Croscarmellose, Triethyl Citrate, Silica, Titanium Dioxide color, Vegetable Magnesium Stearate, Mannitol, Glycerol Palmitostearate, Stearic Acid, Medium Chain Triglycerides.
Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): DOCTOR RECOMMENDED.
How many labels does SAM-e 400 mg Double Strength have?
One label is on file, entered on December 23, 2011.
- Label 3858 (current) Entered December 23, 2011 · off the market December 10, 2013 · 30 enteric coated tablets · UPC 7 16963 50260 3
DSLD also links this label to: SAM-e 400 mg (image difference, same product).
Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).
Who makes it?
The label names PhysioLogics, LLC (distributor), Carbondale, IL, U.S.A.. All PhysioLogics products.