SAM-e
by Nature's Sunshine · tablet or pill · 30 enteric coated tablets
- On the market (NIH)
- UPC 0 99904 01845 7
- DSLD label 255437
- Serving 2 tablets; amounts per 1 tablet
- 15 servings
SAM-e by Nature's Sunshine lists one ingredient: 400 mg of SAM-e per serving of 1 tablet. Its current label entered the NIH Dietary Supplement Label Database on September 24, 2021.
What is in SAM-e?
Each row as the label prints it, per serving of 1 tablet. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).
| Ingredient | Amount | % DV | Among products listing it |
|---|---|---|---|
| SAM-eas S-Adenosylmethionine Tosylate DisulfateSAM-e (Form: from S-Adenosylmethionine Tosylate Disulfate) | 400 mg | Higher than 53% of 163 products listing SAMe (median 200 mg). |
Source: NIH ODS Dietary Supplement Label Database, label 255437 (entered September 24, 2021), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.
Is that a lot?
Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.
The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.
The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.
Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.
Which products have the closest formulas?
6 products list the very same ingredients; the nearest amounts come first.
- SAM-e 400 mgGNC · off the market same ingredients
- SAMe 200 mgBronson Laboratories same ingredients
- Double-Strength SAMe 400Doctor's Best same ingredients
- SAM-e 200 mgFinest Nutrition same ingredients
- SAM-e CompleteNature Made · off the market same ingredients
- SAM-e S-Adenosylmethionine 200 mgPhysioLogics · off the market same ingredients
Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.
What does the label say about taking it?
Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.
- Directions
- Recommended Use: Take 2 tablets daily.
- Warnings
- Caution: Store in a cool dry place out of the reach of children.
- If you are taking prescription antidepressants or have bipolar (manic) depression, consult your physician before and during the use of this product. Pregnant or lactating women should consult their health care provider prior to taking this supplement.
- Do not use if inner seal is missing or damaged.
- Storage
- Refrigerate after opening. Caution: Store in a cool dry place out of the reach of children.
Source: label statements in DSLD label 255437.
What else is on the label?
Other ingredients: S-Adenosyl-L-Methionine Disulfate P-Toluensulfonate, Microcrystalline Cellulose, Magnesium Hydroxide, Stearic Acid, Magnesium Stearate, Silica, Colloidal Anhydrous, Calcium Oxide, Coating.
How many labels does SAM-e have?
4 labels are on file under this name since January 25, 2012: other sizes, label designs and reformulations. The current one leads this page.
- Label 255437 (current) Entered September 24, 2021 · on the market · 30 enteric coated tablets · UPC 0 99904 01845 7
- Label 221068 Entered May 22, 2020 · off the market June 9, 2021 · 30 enteric coated tablets · UPC 0 99904 01845 7
- Label 207580 Entered October 23, 2019 · off the market April 7, 2020 · 30 enteric coated tablets · UPC 0 99904 01845 7
- Label 4586 Entered January 25, 2012 · off the market February 27, 2019 · 30 tablets · UPC 0 99904 01845 7
Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).
Who makes it?
The label names Nature's Sunshine Products, Inc. (manufacturer), Spanish Fork, UT. All Nature's Sunshine products.