Protease 375

by ProEnzol · capsule · 60 vegan capsules

  • On the market (NIH)
  • UPC 7 07636 12711 7
  • DSLD label 322876
  • Serving 1 vegan capsule
  • 60 servings

Protease 375 by ProEnzol lists one ingredient: 375 mg of protease per serving of 1 vegan capsule. Its current label entered the NIH Dietary Supplement Label Database on December 21, 2024.

What is in Protease 375?

Each row as the label prints it, per serving of 1 vegan capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Protease 375: Supplement Facts rows against the market (DSLD label 322876, January 2026 release)
IngredientAmount% DVAmong products listing it
Protease375 mgProteolytic Enzymes (Proteases) in Protease 375 against 327 products375 mg per serving; the middle half of products list 10 mg to 100 mg, the median 30 mg.375 mg

Higher than 93% of 327 products listing proteolytic enzymes (proteases) (median 30 mg). Per day at the most servings: 750 mg.

Source: NIH ODS Dietary Supplement Label Database, label 322876 (entered December 21, 2024), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • Its 375 mg of proteolytic enzymes (proteases) is higher than 93% of the 327 proteolytic enzymes (proteases) products that print an amount; 22 list more.

The NIH database records 1 to 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

6 products list the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: Take one (1) capsule at the beginning of each meal for digestive support or twice daily on an empty stomach for systemic support, or as directed by your healthcare professional.
Warnings
Caution: If you are pregnant, nursing, have a serious medical condition, or take any medications, consult your healthcare professional before use.
Use only if tamper-evident seal is unbroken.
Keep out of reach of children.
Exclusively for professionals
Allergens and what it does not contain
Contains no: Sugar, soy, wheat, yeast, gluten, peanuts, tree nuts, eggs, dairy, animal products, artificial colors, flavors and sweeteners or genetically modified organisms (GMOs).
Storage
Store tightly closed in a cool, dry place.

Source: label statements in DSLD label 322876.

What else is on the label?

Other ingredients: Plant Fiber, Water.

How many labels does Protease 375 have?

2 labels are on file under this name since May 22, 2020: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 322876 (current) Entered December 21, 2024 · on the market · 60 vegan capsules · UPC 7 07636 12711 7
  2. Label 221652 Entered May 22, 2020 · off the market September 18, 2024 · 60 vegan capsules · UPC 7 07636 12711 7

DSLD also links this label to: Protein DigestEnz (image difference, same product).

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Enzymes Inc. (manufacturer), Kansas City, MO, U.S.A.. All ProEnzol products.

Where next?