PlainVitamins

Probio Defense

by XYMOGEN · capsule · 84 vegetarian capsules

  • On the market (NIH)
  • UPC 8 71149 00036 3
  • DSLD label 303824
  • Serving 1 capsule
  • 84 servings

Probio Defense by XYMOGEN lists 5 ingredients, 2 with an amount per serving of 1 capsule, such as 2 mg of zinc and 12.5 mcg of selenium; 3 sit inside a blend without their own amounts. Its current label entered the NIH Dietary Supplement Label Database on December 14, 2023.

What is in Probio Defense?

Each row as the label prints it, per serving of 1 capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Probio Defense: Supplement Facts rows against the market (DSLD label 303824, January 2026 release)
IngredientAmount% DVAmong products listing it
Zincas Zinc Yeast2 mg18%Zinc in Probio Defense against 13,186 products2 mg per serving; the middle half of products list 5 mg to 15 mg, the median 11 mg.DV 11 mgUL 40 mg2 mg

90% of 13,186 products listing zinc give more (median 11 mg). Per day at the most servings: 4 mg.

Seleniumas Selenium Yeast12.5 mcg23%Selenium in Probio Defense against 7,658 products12.5 mcg per serving; the middle half of products list 27 mcg to 100 mcg, the median 55 mcg.DV 55 mcgUL 400 mcg12.5 mcg

93% of 7,658 products listing selenium give more (median 55 mcg). Per day at the most servings: 25 mcg.

Probio Defense Blend51.55 mg
Lactobacillus helveticus Rosell-52in the blend, no amount given
Lactobacillus rhamnosus Rosell-11in the blend, no amount given
Bifidobacterium longum Rosell-175in the blend, no amount given

Source: NIH ODS Dietary Supplement Label Database, label 303824 (entered December 14, 2023), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • 90% of the 13,186 products that print an amount of zinc list more than its 2 mg of zinc (median 11 mg).
  • 93% of the 7,658 products that print an amount of selenium list more than its 12.5 mcg of selenium (median 55 mcg).

The NIH database records 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Probio Defense's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: Take one capsule twice daily before or during meals, or as directed by your healthcare professional.
Warnings
Consult your healthcare professional prior to use.
Individuals taking medication should discuss potential interactions with their healthcare professional.
Do not use if tamper seal is damaged.
Keep out of reach of children.
Contains: Milk and soy.
Allergens and what it does not contain
Formulated to exclude: Wheat, gluten, animal products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.
Storage
Storage: Probio Defense is shipped refrigerated to preserve the shelf life of the strains. In order to maximize shelf life, keep closed in a cool, dry place.

Source: label statements in DSLD label 303824.

What else is on the label?

Other ingredients: Potato Starch, Hypromellose, Water, Magnesium Stearate, Ascorbic Acid.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): Vegetarian caps ePV (ePedigree Verification); Third-Party Verified GMP Compliant.

How many labels does Probio Defense have?

5 labels are on file under this name since February 23, 2012: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 303824 (current) Entered December 14, 2023 · on the market · 84 vegetarian capsules · UPC 8 71149 00036 3
  2. Label 240562 Entered January 22, 2021 · off the market September 8, 2023 · 84 vegetarian capsules · UPC 8 71149 00036 3
  3. Label 66762 Entered November 21, 2016 · off the market July 24, 2019 · 84 vegetarian capsules · UPC 8 71149 00036 3
  4. Label 28160 Entered December 24, 2013 · off the market December 9, 2015 · 84 vegetable capsules · UPC 8 71149 00036 3
  5. Label 5926 Entered February 23, 2012 · off the market September 11, 2012 · 84 vegetable capsules

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names XYMOGEN Exclusive Professional Formulas (distributor), Orlando, FL. All XYMOGEN products.

Where next?