MSM Methylsulfonylmethane Sulfur Complex

by Dr. Mercola · capsule · 60 capsules

  • On the market (NIH)
  • UPC 8 13006 01500 4
  • DSLD label 250217
  • Serving 2 capsules
  • 30 servings

MSM Methylsulfonylmethane Sulfur Complex by Dr. Mercola lists 7 ingredients, 3 with an amount per serving of 2 capsules, such as 1,000 mg of OptiMSM, 100 mg of trimethylglycine and 25 mg of R-alpha lipoic acid; 4 sit inside a blend without their own amounts. Its current label entered the NIH Dietary Supplement Label Database on May 22, 2021.

What is in MSM Methylsulfonylmethane Sulfur Complex?

Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

MSM Methylsulfonylmethane Sulfur Complex: Supplement Facts rows against the market (DSLD label 250217, January 2026 release)
IngredientAmount% DVAmong products listing it
OptiMSM1,000 mgMethylsulfonylmethane in MSM Methylsulfonylmethane Sulfur Complex against 1,454 products1,000 mg per serving; the middle half of products list 150 mg to 1,000 mg, the median 500 mg.1,000 mg

Higher than 74% of 1,454 products listing methylsulfonylmethane (median 500 mg).

Trimethylglycine100 mgBetaine in MSM Methylsulfonylmethane Sulfur Complex against 731 products100 mg per serving; the middle half of products list 50 mg to 1,250 mg, the median 250 mg.100 mg

60% of 731 products listing betaine give more (median 250 mg).

R-Alpha Lipoic Acidas Na-RALA Sodium R-LipoateR-Alpha Lipoic Acid (Form: from Na-RALA Sodium R-Lipoate)25 mgAlpha Lipoic Acid in MSM Methylsulfonylmethane Sulfur Complex against 2,407 products25 mg per serving; the middle half of products list 25 mg to 150 mg, the median 50 mg.25 mg

68% of 2,407 products listing alpha lipoic acid give more (median 50 mg).

Dr. Mercola's Sulfur Blend25 mg
organic Broccoliin the blend, no amount given
organic Garlicin the blend, no amount given
organic Green Cabbagein the blend, no amount given
organic Kalein the blend, no amount given

Source: NIH ODS Dietary Supplement Label Database, label 250217 (entered May 22, 2021), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient; 4 ingredients sit inside a blend, so their amounts cannot be compared.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with MSM Methylsulfonylmethane Sulfur Complex's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested Use: Adults, as a dietary supplement, take two (2) capsules daily.
Warnings
Keep out of reach of children.
Do not use if safety seal is broken.
If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

Source: label statements in DSLD label 250217.

What else is on the label?

Other ingredients: Microcrystalline Cellulose, Capsule, Silicon Dioxide.

How many labels does MSM Methylsulfonylmethane Sulfur Complex have?

2 labels are on file under this name since August 23, 2020: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 250217 (current) Entered May 22, 2021 · on the market · 60 capsules · UPC 8 13006 01500 4
  2. Label 232021 Entered August 23, 2020 · off the market April 23, 2021 · 60 capsules · UPC 8 13006 01500 4

DSLD also links this label to: MSM with Organic Sulfur Complex (image difference, same product), MSM Methylsulfonylmethan Sulfur Complex (image difference, same product).

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names NHP (distributor), Cape Coral, FL. All Dr. Mercola products.

Where next?