PlainVitamins

MSM 434 mg

by Signature Supplements · capsule · 100 capsules

  • On the market (NIH)
  • DSLD label 338850
  • Serving 1 to 2 capsules; amounts per 2 capsules
  • 50 servings

MSM 434 mg by Signature Supplements lists one ingredient: 868 mg of methylsulfonylmethane per serving of 2 capsules. Its current label entered the NIH Dietary Supplement Label Database on September 25, 2025.

What is in MSM 434 mg?

Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

MSM 434 mg: Supplement Facts rows against the market (DSLD label 338850, January 2026 release)
IngredientAmount% DVAmong products listing it
Methylsulfonylmethane868 mgMethylsulfonylmethane in MSM 434 mg against 1,454 products868 mg per serving; the middle half of products list 150 mg to 1,000 mg, the median 500 mg.868 mg

Higher than 72% of 1,454 products listing methylsulfonylmethane (median 500 mg).

Source: NIH ODS Dietary Supplement Label Database, label 338850 (entered September 25, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

6 products list the very same ingredients; the nearest amounts come first.

  • MSM 900Ortho Molecular Products same ingredients
  • Mighty MSMHoltraCeuticals same ingredients
  • MSMBiotics Research Corporation same ingredients
  • MSM 1000GNC · off the market same ingredients
  • MSM 1000 mgVitamin World same ingredients
  • MSM 1000 mgVitabase same ingredients

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: For adults, take one (1) to two (2) capsules daily, preferably with a meal.
Warnings
Keep out of reach of children.
Do not take this product within 2 hours of taking medications or follow the advice of your health care providers. Warning: Pregnant or lactating women should consult a doctor before using any product. Consult doctor before use if you have, or have had, kidney disease, if you are on a magnesium-restricted diet or if you are taking any medications or remedies such as those to treat high blood pressure, heart medications, muscle relaxants or diuretics.
Discontinue use and consult your doctor if any adverse reactions occur, such as gastrointestinal discomfort or low blood pressure.
Not intended for use by persons under the age of 18
Allergens and what it does not contain
No: Chemical Fillers or Binders, Artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.
Storage
Store in a dry place and avoid excessive heat.

Source: label statements in DSLD label 338850.

What else is on the label?

Other ingredients: Cellulose, Diatomaceous Earth.

How many labels does MSM 434 mg have?

One label is on file, entered on September 25, 2025.

  1. Label 338850 (current) Entered September 25, 2025 · on the market · 100 capsules

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Signature Supplements (distributor), San Clemente, CA. All Signature Supplements products.

Where next?