PlainVitamins

Methyldrene 25

by Cloma Pharma Laboratories · capsule · 100 super capsules

  • Off the market since October 2023 (NIH)
  • DSLD label 164483
  • Serving 1 capsule
  • 100 servings

Methyldrene 25 by Cloma Pharma Laboratories lists 17 ingredients, 17 with an amount per serving of 1 capsule, such as 2 mg of vitamin B6, 6 mcg of vitamin B12, 30 mcg of chromium picolinate and 250 mg of caffeine anhydrous. Its current label entered the NIH Dietary Supplement Label Database on November 21, 2018.

What is in Methyldrene 25?

Each row as the label prints it, per serving of 1 capsule. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Methyldrene 25: Supplement Facts rows against the market (DSLD label 164483, January 2026 release)
IngredientAmount% DVAmong products listing it
Vitamin B6as Pyridoxine Hydrochloride2 mg100%Vitamin B6 in Methyldrene 25 against 15,277 products2 mg per serving; the middle half of products list 2 mg to 20 mg, the median 6 mg.DV 1.7 mgUL 100 mg2 mg

69% of 15,277 products listing vitamin B6 give more (median 6 mg).

Vitamin B12as Cyanocobalamin6 mcg100%Vitamin B12 in Methyldrene 25 against 14,425 products6 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg6 mcg

74% of 14,425 products listing vitamin B12 give more (median 36 mcg).

Chromium Picolinate30 mcg25%Chromium Picolinate in Methyldrene 25 against 121 products30 mcg per serving; the middle half of products list 100 mcg to 500 mcg, the median 200 mcg.30 mcg

91% of 121 products listing chromium picolinate give more (median 200 mcg).

Caffeine Anhydrous250 mgCaffeine in Methyldrene 25 against 3,358 products250 mg per serving; the middle half of products list 100 mg to 275 mg, the median 200 mg.250 mg

Higher than 69% of 3,358 products listing caffeine (median 200 mg).

Ephedra Extract25 mg
White Willowas Salicyclic Acid100 mgWhite Willow in Methyldrene 25 against 256 products100 mg per serving; the middle half of products list 80 mg to 400 mg, the median 150 mg.100 mg

55% of 256 products listing white willow give more (median 150 mg).

Methylsynephrine20 mg
Phenylethylamine HCl20 mgPhenylethylamine in Methyldrene 25 against 41 products20 mg per serving; the middle half of products list 37.5 mg to 300 mg, the median 100 mg.20 mg

95% of 41 products listing phenylethylamine give more (median 100 mg).

Citrus aurantiumas SynephrineCitrus aurantium (Form: 30% Synephrine) Genus: Citrus Species: aurantium100 mgBitter orange in Methyldrene 25 against 198 products100 mg per serving; the middle half of products list 50 mg to 200 mg, the median 100 mg.100 mg

40% of 198 products listing bitter orange give more (median 100 mg).

Yohimbine HCl1.5 mgYohimbine in Methyldrene 25 against 141 products1.5 mg per serving; the middle half of products list 2 mg to 4.5 mg, the median 3 mg.1.5 mg

86% of 141 products listing yohimbine give more (median 3 mg).

Green Teaas EGCG, PolyphenolsGreen Tea (Form: 95% Polyphenols, 40% EGCG)15 mgGreen Tea in Methyldrene 25 against 2,595 products15 mg per serving; the middle half of products list 50 mg to 250 mg, the median 100 mg.15 mg

94% of 2,595 products listing green tea give more (median 100 mg).

Panax ginseng extractas GinsenosidesPanax ginseng extract (Form: 4% ginsenosides) Genus: Panax Species: ginseng100 mgOriental Ginseng in Methyldrene 25 against 706 products100 mg per serving; the middle half of products list 30 mg to 200 mg, the median 90 mg.100 mg

Higher than 51% of 706 products listing oriental ginseng (median 90 mg).

Hoodia extractas Cactus25 mgHoodia in Methyldrene 25 against 80 products25 mg per serving; the middle half of products list 143.75 mg to 575 mg, the median 400 mg.25 mg

91% of 80 products listing hoodia give more (median 400 mg).

5-Htp10 mg5-HTP in Methyldrene 25 against 676 products10 mg per serving; the middle half of products list 50 mg to 100 mg, the median 100 mg.10 mg

95% of 676 products listing 5-HTP give more (median 100 mg).

TheobromineTheobromine Note: 99%10 mgTheobromine in Methyldrene 25 against 372 products10 mg per serving; the middle half of products list 50 mg to 100 mg, the median 100 mg.10 mg

96% of 372 products listing theobromine give more (median 100 mg).

Ginger100 mgGinger in Methyldrene 25 against 1,770 products100 mg per serving; the middle half of products list 25 mg to 150 mg, the median 60 mg.100 mg

Higher than 56% of 1,770 products listing ginger (median 60 mg).

CayenneCayenne Note: 40,000 heat units25 mgCapsicum in Methyldrene 25 against 874 products25 mg per serving; the middle half of products list 25 mg to 100 mg, the median 44.5 mg.25 mg

65% of 874 products listing capsicum give more (median 44.5 mg).

Source: NIH ODS Dietary Supplement Label Database, label 164483 (entered November 21, 2018), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • 91% of the 121 products that print an amount of chromium picolinate list more than its 30 mcg of chromium picolinate (median 200 mcg).
  • 95% of the 41 products that print an amount of phenylethylamine list more than its 20 mg of phenylethylamine (median 100 mg).
  • 94% of the 2,595 products that print an amount of green tea list more than its 15 mg of green tea (median 100 mg).
  • 91% of the 80 products that print an amount of hoodia list more than its 25 mg of hoodia (median 400 mg).
  • 95% of the 676 products that print an amount of 5-HTP list more than its 10 mg of 5-htp (filed by NIH under 5-HTP) (median 100 mg).
  • 96% of the 372 products that print an amount of theobromine list more than its 10 mg of theobromine (median 100 mg).

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Methyldrene 25's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Warnings
Warning: Do not exceed recommended dosage
Allergens and what it does not contain
No sugar, starch, or artificial preservatives.

Source: label statements in DSLD label 164483.

How many labels does Methyldrene 25 have?

One label is on file, entered on November 21, 2018.

  1. Label 164483 (current) Entered November 21, 2018 · off the market October 31, 2023 · 100 super capsules

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Cloma Pharma Laboratories (manufacturer). All Cloma Pharma Laboratories products.

Where next?