PlainVitamins

Defend

by Huge Nutrition · capsule · 120 capsules

  • On the market (NIH)
  • UPC 7 28614 77849 7
  • DSLD label 299800
  • Serving 4 capsules
  • 30 servings

Defend by Huge Nutrition lists 7 ingredients, 7 with an amount per serving of 4 capsules, such as 1 g of milk thistle seed extract, 600 mg of N-acetyl cysteine, 500 mg of peppermint, powder and 250 mg of saw palmetto berry extract. Its current label entered the NIH Dietary Supplement Label Database on December 14, 2023.

What is in Defend?

Each row as the label prints it, per serving of 4 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Defend: Supplement Facts rows against the market (DSLD label 299800, January 2026 release)
IngredientAmount% DVAmong products listing it
Milk Thistle Seed Extractas SilymarinStandardized to contain a minimum of 80% Silymarin1 gMilk Thistle in Defend against 1,277 products1,000 mg per serving; the middle half of products list 90 mg to 300 mg, the median 175 mg.1,000 mg

Higher than 95% of 1,277 products listing milk thistle (median 175 mg).

N-Acetyl Cysteine600 mgN-Acetyl Cysteine in Defend against 1,259 products600 mg per serving; the middle half of products list 55 mg to 500 mg, the median 150 mg.600 mg

Higher than 80% of 1,259 products listing N-acetyl cysteine (median 150 mg).

Peppermint, Powder500 mgPeppermint in Defend against 278 products500 mg per serving; the middle half of products list 20 mg to 207.5 mg, the median 50 mg.500 mg

Higher than 85% of 278 products listing peppermint (median 50 mg).

Saw Palmetto Berry Extractas Fatty Acids, SterolsStandardized to contain 85-95% Fatty Acids and Sterols250 mgSaw Palmetto in Defend against 1,109 products250 mg per serving; the middle half of products list 100 mg to 320 mg, the median 200 mg.250 mg

Higher than 56% of 1,109 products listing saw palmetto (median 200 mg).

Tauroursodeoxycholic Acid Sodium250 mgTauroursodeoxycholic Acid in Defend against 33 products250 mg per serving; the middle half of products list 250 mg to 500 mg, the median 255 mg.250 mg

55% of 33 products listing tauroursodeoxycholic acid give more (median 255 mg).

Red Clover Flower Extract200 mgRed Clover in Defend against 279 products200 mg per serving; the middle half of products list 50 mg to 400 mg, the median 150 mg.200 mg

Higher than 57% of 279 products listing red clover (median 150 mg).

Hawthorn Berry, Leaf Extractas Crataegus oxyacantha Berry Extract, Crataegus oxyacantha Leaf Extract150 mgHawthorn in Defend against 589 products150 mg per serving; the middle half of products list 75 mg to 400 mg, the median 200 mg.150 mg

57% of 589 products listing hawthorn give more (median 200 mg).

Source: NIH ODS Dietary Supplement Label Database, label 299800 (entered December 14, 2023), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • Its 1,000 mg of milk thistle is higher than 95% of the 1,277 milk thistle products that print an amount; 29 list more.
  • 55% of the 33 products that print an amount of tauroursodeoxycholic acid list more than its 250 mg of tauroursodeoxycholic acid (median 255 mg).

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Defend's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested use: As a dietary supplement, take four (4) capsules with 8-12 fl oz of water.
Warnings
Warning: For use by healthy adults only, not recommended for persons under the age of 18.
Do not use if you are pregnant or nursing.
Seek advice from a healthcare professional before taking if you have any preexisting medical condition to ensure it is safe to take this product. In case of accidental overdose, contact a poison control center immediately.
Keep out of the reach of children.

Source: label statements in DSLD label 299800.

What else is on the label?

Other ingredients: Gelatin, Rice Flour, Magnesium Stearate, Silicon Dioxide.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): Made in USA GMP Good Manufacturing Practice.

How many labels does Defend have?

One label is on file, entered on December 14, 2023.

  1. Label 299800 (current) Entered December 14, 2023 · on the market · 120 capsules · UPC 7 28614 77849 7

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Huge Nutrition (distributor), Breda, Netherlands. All Huge Nutrition products.

Where next?