DuoZyme
by Karuna · capsule · 180 capsules
- On the market (NIH)
- UPC 0 18647 03104 2
- DSLD label 327089
- Serving 2 capsules
- 90 servings
DuoZyme by Karuna lists 8 ingredients, 5 with an amount per serving of 2 capsules, such as 300 mg of betaine hydrochloride, 300 mg of glutamic HCl, 100 mg of papain and 40 mg of bovine pepsin; 3 sit inside a blend without their own amounts. Its current label entered the NIH Dietary Supplement Label Database on March 25, 2025.
What is in DuoZyme?
Each row as the label prints it, per serving of 2 capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).
| Ingredient | Amount | % DV | Among products listing it |
|---|---|---|---|
| Betaine Hydrochloridegastric phase | 300 mg | Higher than 82% of 914 products listing betaine hydrochloride (median 50 mg). Per day at the most servings: 600 mg. | |
| Glutamic HCl | 300 mg | 75% of 1,850 products listing glutamine give more (median 1 g). Per day at the most servings: 0.6 g. | |
| PapainEnzyme blend, gastric phase | 100 mg | Higher than 77% of 607 products listing papain (median 40 mg). Per day at the most servings: 200 mg. | |
| Bovine PepsinEnzyme blend, 1:15000, gastric phase, equal to 100 mg of 1:3000 strength pepsin, from BSE-free freeze-dried bovine source | 40 mg | 57% of 223 products listing pepsin give more (median 50 mg). Per day at the most servings: 80 mg. | |
| Bovine Pancreatin6x, enzyme blend, duodenal phase, from BSE-free freeze-dried bovine source | 300 mg | ||
| Bovine Ox Bile extractDuodenal phase, from BSE-free freeze-dried bovine source | 120 mg | Higher than 61% of 160 products listing bile (median 100 mg). Per day at the most servings: 240 mg. | |
| ProteaseProviding at least the following, 45,000 USP Units | no amount given | ||
| AmylaseProviding at least the following, 45,000 USP Units | no amount given | ||
| LipaseProviding at least the following, 7,500 USP Units | no amount given |
Source: NIH ODS Dietary Supplement Label Database, label 327089 (entered March 25, 2025), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.
Is that a lot?
Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient; 3 ingredients sit inside a blend, so their amounts cannot be compared.
The NIH database records 2 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.
The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.
Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.
Which products have the closest formulas?
The products whose ingredient lists overlap most with DuoZyme's, rare ingredients counting for more.
- SuperzymesVitabase 7 shared, 82% alike
- Super EnzymesMeijer Naturals 7 shared, 82% alike
- SuperzymesLuckyVitamin 7 shared, 82% alike
- Digestive Enzymes SAPNFH 7 shared, 82% alike
- Enzyme CapsVSN Vital Strength Nutrition · off the market 7 shared, 77% alike
- Enzyme CapsVitaCeutical Labs 7 shared, 77% alike
Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.
What does the label say about taking it?
Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.
- Directions
- Suggested use for adults: Two or more capsules, taken with meals, or as directed by your health care practitioner.
- Warnings
- Warning: Patients with active peptic ulcer should use HCI products with caution.
- This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.
- Storage
- Keep in a cool, dry place, tightly capped.
Source: label statements in DSLD label 327089.
What else is on the label?
Other ingredients: Silica, Stearate, Vegetable Stearine, Maltodextrin.
How many labels does DuoZyme have?
7 labels are on file under this name since August 23, 2013: other sizes, label designs and reformulations. The current one leads this page.
- Label 327089 (current) Entered March 25, 2025 · on the market · 180 capsules · UPC 0 18647 03104 2
- Label 327088 Entered February 23, 2025 · on the market · 90 capsules · UPC 0 18647 03103 5
- Label 262762 Entered May 19, 2022 · off the market September 28, 2023 · 90 capsules · UPC 0 18647 03103 5
- Label 262664 Entered May 19, 2022 · off the market September 28, 2023 · 180 capsules · UPC 0 18647 03104 2
- Label 206144 Entered August 23, 2019 · off the market September 28, 2023 · 180 capsules
- Label 24365 Entered August 23, 2013 · off the market September 20, 2021 · 180 capsules · UPC 0 18647 03104 2
- Label 24362 Entered August 23, 2013 · on the market · 90 capsules
Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).
Who makes it?
The label names Karuna Corporation (manufacturer), Novato, CA. All Karuna products.