PlainVitamins

Double Strength Zymactive Proteolytic Enzymes

by Natural Factors · tablet or pill · 30 enteric coated tablets

  • Off the market since May 2017 (NIH)
  • UPC 0 68958 01752 5
  • DSLD label 8446
  • Serving 1 to 2 tablets; amounts per 2 tablets
  • 15 servings

Double Strength Zymactive Proteolytic Enzymes by Natural Factors lists 3 ingredients, 3 with an amount per serving of 2 tablets, such as 240 mg of papain, 104 mg of serratiopeptidase and 100 mg of bromelain. Its current label entered the NIH Dietary Supplement Label Database on June 1, 2012.

What is in Double Strength Zymactive Proteolytic Enzymes?

Each row as the label prints it, per serving of 2 tablets. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Double Strength Zymactive Proteolytic Enzymes: Supplement Facts rows against the market (DSLD label 8446, January 2026 release)
IngredientAmount% DVAmong products listing it
Pancreatin 8XPancreatin 8X Note: 8 times more concentrated than USP standard400 mg
PapainPapain Note: 30,000 USP/mg240 mgPapain in Double Strength Zymactive Proteolytic Enzymes against 607 products240 mg per serving; the middle half of products list 20 mg to 75 mg, the median 40 mg.240 mg

Higher than 95% of 607 products listing papain (median 40 mg). Per day at the most servings: 720 mg.

SerratiopeptidaseSerratia peptidase Note: 200,000 SPU/g104 mgSerratiopeptidase in Double Strength Zymactive Proteolytic Enzymes against 64 products104 mg per serving; the middle half of products list 16.25 mg to 74.25 mg, the median 33 mg.104 mg

Higher than 83% of 64 products listing serratiopeptidase (median 33 mg). Per day at the most servings: 312 mg.

BromelainBromelain 1,200 MCU/g100 mgBromelain in Double Strength Zymactive Proteolytic Enzymes against 1,337 products100 mg per serving; the middle half of products list 25 mg to 200 mg, the median 50 mg.100 mg

Higher than 55% of 1,337 products listing bromelain (median 50 mg). Per day at the most servings: 300 mg.

Source: NIH ODS Dietary Supplement Label Database, label 8446 (entered June 1, 2012), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • Its 240 mg of papain is higher than 95% of the 607 papain products that print an amount; 26 list more.

The NIH database records 2 to 3 servings a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

1 product lists the very same ingredients; the nearest amounts come first.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested Usage: 1-2 tablets 2-3 times per day on an empty stomach with water.
Warnings
Keep out of reach of children.
Sealed for your protection. Do not use if seal is broken.
Consult your health professional before taking this product, especially if you are pregnant, nursing, having surgery or taking any medication.
Allergens and what it does not contain
Contains no artificial preservatives, color or sweeteners; no yeast.
Storage
For freshness, store in a cool, dry place.

Source: label statements in DSLD label 8446.

What else is on the label?

Other ingredients: Cellulose, purified Water, enteric coating, Croscarmellose Sodium, Magnesium Stearate.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): (recycle) Recyclable container; Purity & Potency Guaranteed.

How many labels does Double Strength Zymactive Proteolytic Enzymes have?

2 labels are on file under this name since June 1, 2012: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 8446 (current) Entered June 1, 2012 · off the market May 6, 2017 · 30 enteric coated tablets · UPC 0 68958 01752 5
  2. Label 8445 Entered June 1, 2012 · off the market September 16, 2015 · 90 enteric coated tablets · UPC 0 68958 01750 1

DSLD also links this label to: Double Strength Zymactive (package size difference, same product), Double Strength Zymactive (package size difference, same product), Double Strength Zymactive (image difference, same product), Double Strength Zymactive (package size difference, same product), Double Strength Zymactive (image difference, same product), Double Strength Zymactive (package size difference, same product), Double Strength Zymactive (image difference, same product).

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Natural Factors Canada (manufacturer). All Natural Factors products.

Where next?