Digestive Enzyme

by Nature's Plus · tablet or pill · 90 tablets

  • Off the market since February 2022 (NIH)
  • UPC 0 97467 04450 0
  • DSLD label 68727
  • Serving 1 tablet

Digestive Enzyme by Nature's Plus lists 6 ingredients, 6 with an amount per serving of 1 tablet, such as 129 mg of ox bile extract, 60 mg of glutamic acid hydrochloride, 60 mg of amylase and 45 mg of pepsin. Its current label entered the NIH Dietary Supplement Label Database on December 23, 2016.

What is in Digestive Enzyme?

Each row as the label prints it, per serving of 1 tablet. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Digestive Enzyme: Supplement Facts rows against the market (DSLD label 68727, January 2026 release)
IngredientAmount% DVAmong products listing it
Pancreatin 4XPancreatin 4X Note: (quadruple strength) (equivalent to Pancreatin USP 516 mg)129 mg
Ox Bile extract129 mgBile in Digestive Enzyme against 160 products129 mg per serving; the middle half of products list 50 mg to 129.25 mg, the median 100 mg.129 mg

Higher than 71% of 160 products listing bile (median 100 mg).

Glutamic Acid Hydrochloride60 mgGlutamic Acid in Digestive Enzyme against 697 products60 mg per serving; the middle half of products list 25 mg to 364 mg, the median 80 mg.60 mg

53% of 697 products listing glutamic acid give more (median 80 mg).

Amylaseas Aspergillus oryzaeAmylase (Form: from Aspergillus oryzae fermentation Genus: Aspergillus Species: oryzae)60 mgAmylase in Digestive Enzyme against 326 products60 mg per serving; the middle half of products list 5 mg to 50 mg, the median 14 mg.60 mg

Higher than 81% of 326 products listing amylase (median 14 mg).

PepsinPepsin Note: (1:10,000) (equivalent to Pepsin NF 150 mg)45 mgPepsin in Digestive Enzyme against 223 products45 mg per serving; the middle half of products list 25 mg to 130 mg, the median 50 mg.45 mg

55% of 223 products listing pepsin give more (median 50 mg).

PapainPapain (Form: from Papaya)30 mgPapain in Digestive Enzyme against 607 products30 mg per serving; the middle half of products list 20 mg to 75 mg, the median 40 mg.30 mg

52% of 607 products listing papain give more (median 40 mg).

Methylcellulose15 mg

Source: NIH ODS Dietary Supplement Label Database, label 68727 (entered December 23, 2016), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

Every amount on this label with a position sits within the middle 80% of the products that list the same ingredient.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Digestive Enzyme's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Directions: As a dietary supplement, one tablet as symptoms occur.
Warnings
If symptoms of digestive discomfort persist, discontinue use and consult a physician.
Not to be used by children under 12 unless recommended by a physician.
Warnings: Keep tightly closed in a cool, dry place and out of reach of children.
Allergens and what it does not contain
Free from artificial colors and preservatives. Free from the common allergens yeast, wheat, soy and milk.

Source: label statements in DSLD label 68727.

What else is on the label?

Other ingredients: Microcrystalline Cellulose, Di-Calcium Phosphate, Vegetable Cellulose, Stearic Acid, Magnesium Stearate, Silica, Pharmaceutical Glaze.

How many labels does Digestive Enzyme have?

3 labels are on file under this name since October 1, 2012: other sizes, label designs and reformulations. The current one leads this page.

  1. Label 68727 (current) Entered December 23, 2016 · off the market February 28, 2022 · 90 tablets · UPC 0 97467 04450 0
  2. Label 49403 Entered August 25, 2015 · off the market November 30, 2016 · 90 tablets · UPC 0 97467 04450 0
  3. Label 13244 Entered October 1, 2012 · off the market July 31, 2015 · 90 tablets · UPC 0 97467 04450 0

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Natural Organics Laboratories, Inc. makers of Nature's Plus (manufacturer), Amityville, New York. All Nature's Plus products.

Where next?