PlainVitamins

Defender

by Renue By Science · capsule · 120 capsules

  • On the market (NIH)
  • UPC 6 56165 99646 9
  • DSLD label 319002
  • Serving 2 vegetarian capsules
  • 60 servings

Defender by Renue By Science lists 4 ingredients, 4 with an amount per serving of 2 vegetarian capsules. Its current label entered the NIH Dietary Supplement Label Database on September 25, 2024.

What is in Defender?

Each row as the label prints it, per serving of 2 vegetarian capsules. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Defender: Supplement Facts rows against the market (DSLD label 319002, January 2026 release)
IngredientAmount% DVAmong products listing it
Defender800 mg
Vitamin Cliposomal500 mg556%*Vitamin C in Defender against 18,583 products500 mg per serving; the middle half of products list 60 mg to 270 mg, the median 100 mg.DV 90 mgUL 2,000 mg500 mg

Higher than 81% of 18,583 products listing vitamin C (median 100 mg).

Calcium Alpha-Ketoglutarateliposomal150 mg12%*Calcium in Defender against 17,831 products150 mg per serving; the middle half of products list 50 mg to 252 mg, the median 115 mg.DV 1,300 mgUL 2,500 mg150 mg

Higher than 58% of 17,831 products listing calcium (median 115 mg).

Palmitoylethanolamideliposomal75 mgPalmitoylethanolamide in Defender against 65 products75 mg per serving; the middle half of products list 300 mg to 600 mg, the median 350 mg.75 mg

92% of 65 products listing palmitoylethanolamide give more (median 350 mg).

Hyaluronic Acidliposomal75 mgHyaluronic acid in Defender against 900 products75 mg per serving; the middle half of products list 10 mg to 100 mg, the median 50 mg.75 mg

Higher than 62% of 900 products listing hyaluronic acid (median 50 mg).

* % Daily Value computed from the printed amount and the FDA Daily Value (21 CFR 101.9); the label prints none for that row.

Source: NIH ODS Dietary Supplement Label Database, label 319002 (entered September 25, 2024), version 9.4.0. See the label on DSLD or its label image (PDF). Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • 92% of the 65 products that print an amount of palmitoylethanolamide list more than its 75 mg of palmitoylethanolamide (median 350 mg).

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

Which products have the closest formulas?

The products whose ingredient lists overlap most with Defender's, rare ingredients counting for more.

Source: ingredient lists of every product's current label in DSLD (version 9.4.0); similarity weights each shared ingredient by how rare it is.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Suggested Use Take two (2) capsules daily with or without food. May be taken with or without food.
Warnings
Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using.
Do not use if safety seal is broken or missing.
Allergens and what it does not contain
No artificial colors, flavors or preservatives. Non-GMO.
Storage
Store in a cool, dry place.

Source: label statements in DSLD label 319002.

What else is on the label?

Other ingredients: Cellulose, Sunflower Lecithin, Rice Flour, Microcrystalline Cellulose, Passion Flower extract.

Seals and symbols as the label prints them (the maker's; a certifier's own list confirms a seal): GMP Good Manufacturing Practice Certified.

How many labels does Defender have?

One label is on file, entered on September 25, 2024.

  1. Label 319002 (current) Entered September 25, 2024 · on the market · 120 capsules · UPC 6 56165 99646 9

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Renue By Science (distributor), Jacksonville, FL. All Renue By Science products.

Where next?