PlainVitamins

Cerefolin NAC

by Alfasigma · other (e.g. tea bag) · 90 caplets

  • On the market (NIH)
  • DSLD label 206099
  • Serving 1 caplet

Cerefolin NAC by Alfasigma lists 4 ingredients, 4 with an amount per serving of 1 caplet, such as 6 mg of L-methylfolate calcium, 90.31 mg of algae-S powder, 2 mg of methylcobalamin and 600 mg of N-acetyl-L-cysteine. Its current label entered the NIH Dietary Supplement Label Database on August 23, 2019.

What is in Cerefolin NAC?

Each row as the label prints it, per serving of 1 caplet. The capsule beside an amount places it among every product in the NIH database that lists the same ingredient: the bar is the middle half of their amounts, the line in it the median, the whiskers the 10th and 90th percentiles; the green tick is the FDA Daily Value and the red dashed tick the adult upper limit (IOM).

Cerefolin NAC: Supplement Facts rows against the market (DSLD label 206099, January 2026 release)
IngredientAmount% DVAmong products listing it
L-Methylfolate Calcium6 mgFolate in Cerefolin NAC against 7,022 products6,000 mcg per serving; the middle half of products list 200 mcg to 400 mcg, the median 400 mcg.6,000 mcg

Higher than over 99% of 7,022 products listing folate (median 400 mcg).

Algae-S Powder90.31 mg
Methylcobalamin2 mg83,333%*Vitamin B12 in Cerefolin NAC against 14,425 products2,000 mcg per serving; the middle half of products list 6 mcg to 200 mcg, the median 36 mcg.DV 2.4 mcg2,000 mcg

Higher than 96% of 14,425 products listing vitamin B12 (median 36 mcg).

N-Acetyl-L-Cysteine600 mgN-Acetyl Cysteine in Cerefolin NAC against 1,259 products600 mg per serving; the middle half of products list 55 mg to 500 mg, the median 150 mg.600 mg

Higher than 80% of 1,259 products listing N-acetyl cysteine (median 150 mg).

* % Daily Value computed from the printed amount and the FDA Daily Value (21 CFR 101.9); the label prints none for that row.

Source: NIH ODS Dietary Supplement Label Database, label 206099 (entered August 23, 2019), version 9.4.0. See the label on DSLD. Amounts are what the maker printed; DSLD does not test products. Daily Values: the FDA's Daily Value page.

Is that a lot?

The rows in the top or bottom tenth of the products that list the same ingredient, and any above the adult upper limit at the most servings a day the directions give:

  • Its 6,000 mcg of L-methylfolate calcium (filed by NIH under folate) is higher than over 99% of the 7,022 folate products that print an amount; 68 list more.
  • Its 2,000 mcg of methylcobalamin (filed by NIH under vitamin B12) is higher than 96% of the 14,425 vitamin B12 products that print an amount; 529 list more.

The NIH database records one serving a day from the label's directions; its % Daily Values are for adults and children 4 or more years of age. The directions as printed are further down this page.

The Tolerable Upper Intake Level is the most of a nutrient per day, from food, water and supplements together, that is likely to pose no risk for almost all adults (Institute of Medicine, 2011). It does not apply under medical supervision. This page compares labels; it is not medical advice.

Sources: amounts from the DSLD label; Daily Values from 21 CFR 101.9(c)(8)(iv); adult upper limits from the Institute of Medicine's DRI summary tables (2011). How positions are computed.

What does the label say about taking it?

Quoted from the label as DSLD transcribed it: the maker's words, including any claim about what the product does, which the FDA has not evaluated and PlainVitamins does not endorse.

Directions
Recommended use The usual adult dose is one caplet daily or as directed under medical supervision.
Warnings
Contains milk and soy
CerefolinNAC is a prescription medical food for use only under the supervision of a physician.
Medical foods are intended for a patient who has a limited or impaired capacity to ingest, digest, absorb, or metabolize ordinary foodstuffs or certain nutrients, or who has other special medically determined nutrient requirements, the dietary management of which cannot be achieved by the modification of the normal diet alone.
Contraindications CerefolinNAC is contraindicated in patients with known hypersensitivity to any of the components contained in this product.
Precautions General Folic acid, when administered in daily doses above 0.1mg, may obscure the detection of B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations). L-methylfolate Calcium may be less likely than folic acid to mask vitamin B12 deficiency. Folate therapy alone is inadequate for the treatment of a B12 deficiency.
N-acetyl-L-cysteine should be avoided by nursing mothers.
N-acetyl-L-cysteine clearance is reduced in those with chronic liver disease as well as in pre-term newborns.
Headaches may be intensified in those taking N-acetyl-L-cysteine and nitrates for the treatment of angina.24 While the incidence of renal stones is low, those that do form renal stones, particularly cysteine stones should avoid CerefolinNAC. Do not administer CerefolinNAC to critically ill patients. N-acetyl-L-cysteine and its sulfhydryl metabolites could produce a false-positive result in the nitroprusside test for ketone bodies used in diabetes.24 N-acetyl-L-cysteine should be used with caution in those with a history of peptic ulcer disease since N-acetyl-L-cysteine may disrupt the gastric mucosal barrier.
Adverse reactions Allergic reactions have been reported following the use of oral L-methylfolate Calcium. Mild transient diarrhea, itching, transitory exanthema and the feeling of swelling of the entire body has been associated with methylcobalamin. Nausea, vomiting, diarrhea, transient skin rash, flushing, epigastric pain, and constipation have been associated with N-acetyl-L-cysteine.
Use under medical supervision.
Allergens and what it does not contain
CerefolinNAC caplets do not contain lactose, yeast or gluten.
Storage
Storage Store at controlled room temperature 15(0)C to 30(0)C (59(0)F to 86(0)F) (See USP). Protect from heat, light and moisture.

Source: label statements in DSLD label 206099.

What else is on the label?

Other ingredients: N-Acetyl-L-Cysteine, silicified Microcrystalline Cellulose, Algae-S Powder, Polyvinyl Alcohol, Croscarmellose Sodium, Titanium Dioxide, Polyethylene Glycol 3350, L-Methylfolate Calcium, Magnesium Stearate, Talc, Methylcobalamin, Beet powder, Caramel, Carnauba wax.

How many labels does Cerefolin NAC have?

One label is on file, entered on August 23, 2019.

  1. Label 206099 (current) Entered August 23, 2019 · on the market · 90 caplets

Source: DSLD label entry and market events, version 9.4.0 (labels entered through September 25, 2025).

Who makes it?

The label names Alfasigma USA, Inc. (distributor), Covington, LA. All Alfasigma products.

Where next?